Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

Literature DB >> 24412543

Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

Meng Wang¹, Mirko Beissner¹, Huimin Zhao².

Abstract

Aryl-aldehydes are a common feature in fungal polyketides, which are considered to be exclusively generated by the R domain of nonreducing polyketide synthases (NR-PKSs). However, by cloning and heterologous expression of both cryptic NR-PKS and nonribosomal peptide synthase (NRPS)-like genes from Aspergillus terreus in Saccharomyces cerevisiae, we identified a distinct mechanism for aryl-aldehyde formation in which a NRPS-like protein activates and reduces an aryl-acid produced by the accompanying NR-PKS to an aryl-aldehyde. Bioinformatics study indicates that such a mechanism may be widely used throughout the fungi kingdom.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2014 PMID： 24412543 PMCID： PMC3943900 DOI： 10.1016/j.chembiol.2013.12.005

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

38 in total

1. Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae.

Authors: Songsak Wattanachaisaereekul; Anna Eliasson Lantz; Michael Lynge Nielsen; Olafur S Andrésson; Jens Nielsen
Journal: Biotechnol Bioeng Date: 2007-07-01 Impact factor: 4.530

2. Nongenetic reprogramming of a fungal highly reducing polyketide synthase.

Authors: Ahmed A Yakasai; Jack Davison; Zahida Wasil; Laura M Halo; Craig P Butts; Colin M Lazarus; Andrew M Bailey; Thomas J Simpson; Russell J Cox
Journal: J Am Chem Soc Date: 2011-06-28 Impact factor: 15.419

3. The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules.

Authors: Tobias A M Gulder; Michael F Freeman; Jörn Piel
Journal: Top Curr Chem Date: 2011-03-01

4. Purification, characterization, and properties of an aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646.

Authors: T Li; J P Rosazza
Journal: J Bacteriol Date: 1997-06 Impact factor: 3.490

5. Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.

Authors: Yanran Li; Yit-Heng Chooi; Yuewei Sheng; Joan S Valentine; Yi Tang
Journal: J Am Chem Soc Date: 2011-09-14 Impact factor: 15.419

6. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.

Authors: Volker Schroeckh; Kirstin Scherlach; Hans-Wilhelm Nützmann; Ekaterina Shelest; Wolfgang Schmidt-Heck; Julia Schuemann; Karin Martin; Christian Hertweck; Axel A Brakhage
Journal: Proc Natl Acad Sci U S A Date: 2009-08-06 Impact factor: 11.205

7. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.

Authors: Manmeet Ahuja; Yi-Ming Chiang; Shu-Lin Chang; Mike B Praseuth; Ruth Entwistle; James F Sanchez; Hsien-Chun Lo; Hsu-Hua Yeh; Berl R Oakley; Clay C C Wang
Journal: J Am Chem Soc Date: 2012-05-01 Impact factor: 15.419

Review 8. Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.

Authors: K L Kavanagh; H Jörnvall; B Persson; U Oppermann
Journal: Cell Mol Life Sci Date: 2008-12 Impact factor: 9.261

9. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways.

Authors: Zengyi Shao; Hua Zhao; Huimin Zhao
Journal: Nucleic Acids Res Date: 2008-12-12 Impact factor: 16.971

10. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster.

Authors: Yunzi Luo; Hua Huang; Jing Liang; Meng Wang; Lu Lu; Zengyi Shao; Ryan E Cobb; Huimin Zhao
Journal: Nat Commun Date: 2013 Impact factor: 14.919

17 in total

1. Functional and phylogenetic divergence of fungal adenylate-forming reductases.

Authors: Daniel Kalb; Gerald Lackner; Dirk Hoffmeister
Journal: Appl Environ Microbiol Date: 2014-08-01 Impact factor: 4.792

2. Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.

Authors: Juliane Macheleidt; Kirstin Scherlach; Toni Neuwirth; Wolfgang Schmidt-Heck; Maria Straßburger; Joseph Spraker; Joshua A Baccile; Frank C Schroeder; Nancy P Keller; Christian Hertweck; Thorsten Heinekamp; Axel A Brakhage
Journal: Mol Microbiol Date: 2015-03-11 Impact factor: 3.501

Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

1. Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae.

2. Nongenetic reprogramming of a fungal highly reducing polyketide synthase.

3. The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules.

4. Purification, characterization, and properties of an aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646.

5. Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.

6. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.

7. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.

Review 8. Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.

9. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways.

10. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster.

1. Functional and phylogenetic divergence of fungal adenylate-forming reductases.

2. Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.

Review 3. Genetic platforms for heterologous expression of microbial natural products.

4. Complete Stereoinversion of l-Tryptophan by a Fungal Single-Module Nonribosomal Peptide Synthetase.

Review 5. Engineered biosynthesis of natural products in heterologous hosts.

Review 6. Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases.

7. Pictet-Spengler reaction-based biosynthetic machinery in fungi.

Review 8. Non-ribosomal peptide synthetases: Identifying the cryptic gene clusters and decoding the natural product.

Review 9. Recent advances in genome mining of secondary metabolites in Aspergillus terreus.

10. Trametes versicolor carboxylate reductase uncovered.