Literature DB >> 21675761

Nongenetic reprogramming of a fungal highly reducing polyketide synthase.

Ahmed A Yakasai1, Jack Davison, Zahida Wasil, Laura M Halo, Craig P Butts, Colin M Lazarus, Andrew M Bailey, Thomas J Simpson, Russell J Cox.   

Abstract

The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase.

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Year:  2011        PMID： 21675761     DOI： 10.1021/ja204200x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  15 in total

1.  Regulatory cascade and biological activity of Beauveria bassiana oosporein that limits bacterial growth after host death.

Authors:  Yanhua Fan; Xi Liu; Nemat O Keyhani; Guirong Tang; Yan Pei; Wenwen Zhang; Sheng Tong
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-13       Impact factor: 11.205

2.  Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of an Additional Secondary Metabolite.

Authors:  Karen M VanderMolen; Blaise A Darveaux; Wei-Lun Chen; Steven M Swanson; Cedric J Pearce; Nicholas H Oberlies
Journal:  RSC Adv       Date:  2014-01-01       Impact factor: 3.361

3.  An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in Aspergillus sp. AST0006, an endophytic fungus of Astragalus lentiginosus.

Authors:  Marcelo R de Amorim; E M Kithsiri Wijeratne; Shengliang Zhou; A Elizabeth Arnold; Andrea N L Batista; João M Batista; Lourdes C Dos Santos; A A Leslie Gunatilaka
Journal:  Tetrahedron       Date:  2020-08-22       Impact factor: 2.457

4.  Aryl-aldehyde formation in fungal polyketides: discovery and characterization of a distinct biosynthetic mechanism.

Authors:  Meng Wang; Mirko Beissner; Huimin Zhao
Journal:  Chem Biol       Date:  2014-01-09

5.  An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.

Authors:  Juliana R Gubiani; E M Kithsiri Wijeratne; Taoda Shi; Angela R Araujo; A Elizabeth Arnold; Eli Chapman; A A Leslie Gunatilaka
Journal:  Bioorg Med Chem       Date:  2017-02-03       Impact factor: 3.641

6.  Epigenetic genome mining of an endophytic fungus leads to the pleiotropic biosynthesis of natural products.

Authors:  Xu-Ming Mao; Wei Xu; Dehai Li; Wen-Bing Yin; Yit-Heng Chooi; Yong-Quan Li; Yi Tang; Youcai Hu
Journal:  Angew Chem Int Ed Engl       Date:  2015-05-27       Impact factor: 15.336

7.  Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.

Authors:  Chen Wang; Xiaojing Wang; Liwen Zhang; Qun Yue; Qingpei Liu; Ya-Ming Xu; A A Leslie Gunatilaka; Xiaoyi Wei; Yuquan Xu; István Molnár
Journal:  J Am Chem Soc       Date:  2020-09-23       Impact factor: 15.419

8.  Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.

Authors:  Yaoyao Li; Haotong Chen; Yanjiao Ding; Yunxuan Xie; Haoxin Wang; Ronald L Cerny; Yuemao Shen; Liangcheng Du
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-30       Impact factor: 15.336

9.  Rational reprogramming of fungal polyketide first-ring cyclization.

Authors:  Yuquan Xu; Tong Zhou; Zhengfu Zhou; Shiyou Su; Sue A Roberts; William R Montfort; Jia Zeng; Ming Chen; Wei Zhang; Min Lin; Jixun Zhan; István Molnár
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-18       Impact factor: 11.205

Review 10.  On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.

Authors:  Brandon T Pfannenstiel; Nancy P Keller
Journal:  Biotechnol Adv       Date:  2019-02-07       Impact factor: 14.227
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