BIAS IN LINEAR MODEL POWER AND SAMPLE SIZE DUE TO ESTIMATING VARIANCE.

Planning a study using the General Linear Univariate Model often involves sample size calculation based on a variance estimated in an earlier study. Noncentrality, power, and sample size inherit the randomness. Additional complexity arises if the estimate has been censored. Left censoring occurs when only significant tests lead to a power calculation, while right censoring occurs when only non-significant tests lead to a power calculation. We provide simple expressions for straightforward computation of the distribution function, moments, and quantiles of the censored variance estimate, estimated noncentrality, power, and sample size. We also provide convenient approximations and evaluate their accuracy. The results allow demonstrating that ignoring right censoring falsely widens confidence intervals for noncentrality and power, while ignoring left censoring falsely narrows the confidence intervals. The new results allow assessing and avoiding the potentially substantial bias that censoring may create.