Literature DB >> 24363466

Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.

Ginamarie Debevec1, Wenteng Chen2, Yongping Yu3, Richard A Houghten1, Marc A Giulianotti1.   

Abstract

A libraries from libraries approach is described for the synthesis of five different sulfonamide linked scaffolds. Four of the scaffolds are sulfonamides linked to heterocycles; piperazine, thiourea, cyclic guanidine, and dimethyl cyclic guanidine. The fifth scaffold is a polyamine linked sulfonamide. Three different diversity positions were effectively incorporated into each scaffold providing a number of different compounds with good yields and purity.

Entities:  

Keywords:  guanidine; libraries from libraries; piperazine; positional scanning; sulfonamide; urea

Year:  2013        PMID： 24363466      PMCID： PMC3867824          DOI： 10.1016/j.tetlet.2013.06.003

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  11 in total

Review 1.  Mixture-based synthetic combinatorial libraries.

Authors:  R A Houghten; C Pinilla; J R Appel; S E Blondelle; C T Dooley; J Eichler; A Nefzi; J M Ostresh
Journal:  J Med Chem       Date:  1999-09-23       Impact factor: 7.446

2.  Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

Authors:  Clemencia Pinilla; Jon R Appel; Eva Borràs; Richard A Houghten
Journal:  Nat Med       Date:  2003-01       Impact factor: 53.440

Review 3.  Expanding the medicinally relevant chemical space with compound libraries.

Authors:  Fabian López-Vallejo; Marc A Giulianotti; Richard A Houghten; José L Medina-Franco
Journal:  Drug Discov Today       Date:  2012-04-10       Impact factor: 7.851

4.  Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials.

Authors:  R Suhas; S Chandrashekar; D Channe Gowda
Journal:  Eur J Med Chem       Date:  2011-12-14       Impact factor: 6.514

5.  Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.

Authors:  Richard A Houghten; Clemencia Pinilla; Marc A Giulianotti; Jon R Appel; Colette T Dooley; Adel Nefzi; John M Ostresh; Yongping Yu; Gerald M Maggiora; Jose L Medina-Franco; Daniela Brunner; Jeff Schneider
Journal:  J Comb Chem       Date:  2007-12-08

Review 6.  Shifting from the single to the multitarget paradigm in drug discovery.

Authors:  José L Medina-Franco; Marc A Giulianotti; Gregory S Welmaker; Richard A Houghten
Journal:  Drug Discov Today       Date:  2013-01-20       Impact factor: 7.851

7.  Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.

Authors:  Christopher T Walsh; Steven J Malcolmson; Travis S Young
Journal:  ACS Chem Biol       Date:  2012-01-17       Impact factor: 5.100

8.  Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.

Authors:  Stefania Ferrari; Marco Ingrami; Fabrizia Soragni; Rebecca C Wade; M Paola Costi
Journal:  Bioorg Med Chem Lett       Date:  2012-12-07       Impact factor: 2.823

9.  Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds.

Authors:  Adel Nefzi; John M Ostresh; Yongping Yu; Jongping Yu; Richard A Houghten
Journal:  J Org Chem       Date:  2004-05-28       Impact factor: 4.354

10.  Inhibitory evaluation of sulfonamide chalcones on β-secretase and acylcholinesterase.

Authors:  Jae Eun Kang; Jung Keun Cho; Marcus J Curtis-Long; Hyung Won Ryu; Jin Hyo Kim; Hye Jin Kim; Heung Joo Yuk; Dae Wook Kim; Ki Hun Park
Journal:  Molecules       Date:  2012-12-21       Impact factor: 4.411
View more
  1 in total

1.  Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library.

Authors:  Laura D Hamel; Brian J Lenhart; David A Mitchell; Radleigh G Santos; Marc A Giulianotti; Robert J Deschenes
Journal:  Comb Chem High Throughput Screen       Date:  2016       Impact factor: 1.339
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.