Literature DB >> 18067268

Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.

Richard A Houghten1, Clemencia Pinilla, Marc A Giulianotti, Jon R Appel, Colette T Dooley, Adel Nefzi, John M Ostresh, Yongping Yu, Gerald M Maggiora, Jose L Medina-Franco, Daniela Brunner, Jeff Schneider.   

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Year:  2007        PMID： 18067268     DOI： 10.1021/cc7001205

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


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  61 in total

1.  Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.

Authors:  Marc C Rideout; Jeffrey L Boldt; Gabriel Vahi-Ferguson; Peter Salamon; Adel Nefzi; John M Ostresh; Marc Giulianotti; Clemencia Pinilla; Anca M Segall
Journal:  Mol Divers       Date:  2011-09-22       Impact factor: 2.943

2.  Integrating computational and mixture-based screening of combinatorial libraries.

Authors:  Austin B Yongye; Clemencia Pinilla; Jose L Medina-Franco; Marc A Giulianotti; Colette T Dooley; Jon R Appel; Adel Nefzi; Thomas Scior; Richard A Houghten; Karina Martínez-Mayorga
Journal:  J Mol Model       Date:  2010-09-21       Impact factor: 1.810

3.  Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.

Authors:  Clemencia Pinilla; Bruce S Edwards; Jon R Appel; Tina Yates-Gibbins; Marc A Giulianotti; Jose L Medina-Franco; Susan M Young; Radleigh G Santos; Larry A Sklar; Richard A Houghten
Journal:  Mol Pharmacol       Date:  2013-06-20       Impact factor: 4.436

4.  Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency.

Authors:  Hassan Al-Ali; Ginamarie Debevec; Radleigh G Santos; Richard A Houghten; Jennifer C Davis; Adel Nefzi; Vance P Lemmon; John L Bixby; Marc A Giulianotti
Journal:  ACS Med Chem Lett       Date:  2018-09-24       Impact factor: 4.345

Review 5.  Shifting from the single to the multitarget paradigm in drug discovery.

Authors:  José L Medina-Franco; Marc A Giulianotti; Gregory S Welmaker; Richard A Houghten
Journal:  Drug Discov Today       Date:  2013-01-20       Impact factor: 7.851

6.  Synthetic small-molecule prohormone convertase 2 inhibitors.

Authors:  Dorota Kowalska; Jin Liu; Jon R Appel; Akihiko Ozawa; Adel Nefzi; Robert B Mackin; Richard A Houghten; Iris Lindberg
Journal:  Mol Pharmacol       Date:  2008-12-12       Impact factor: 4.436

7.  A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.

Authors:  Rachel M Sammons; Nicole A Perry; Yangmei Li; Eun Jeong Cho; Andrea Piserchio; Diana P Zamora-Olivares; Ranajeet Ghose; Tamer S Kaoud; Ginamarie Debevec; Chandra Bartholomeusz; Vsevolod V Gurevich; Tina M Iverson; Marc Giulianotti; Richard A Houghten; Kevin N Dalby
Journal:  ACS Chem Biol       Date:  2019-05-13       Impact factor: 5.100

8.  Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.

Authors:  Ginamarie Debevec; Wenteng Chen; Yongping Yu; Richard A Houghten; Marc A Giulianotti
Journal:  Tetrahedron Lett       Date:  2013-08-07       Impact factor: 2.415

9.  Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.

Authors:  José L Medina-Franco; Bruce S Edwards; Clemencia Pinilla; Jon R Appel; Marc A Giulianotti; Radleigh G Santos; Austin B Yongye; Larry A Sklar; Richard A Houghten
Journal:  J Chem Inf Model       Date:  2013-06-07       Impact factor: 4.956

10.  Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Authors:  Austin B Yongye; Jon R Appel; Marc A Giulianotti; Colette T Dooley; Jose L Medina-Franco; Adel Nefzi; Richard A Houghten; Karina Martínez-Mayorga
Journal:  Bioorg Med Chem       Date:  2009-06-21       Impact factor: 3.641
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