Literature DB >> 24327694

Teaching an old dog new tricks: drug repositioning in small cell lung cancer.

Jing Wang1, Lauren Averett Byers.   

Abstract

Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases. ©2013 AACR.

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Year:  2013        PMID： 24327694      PMCID： PMC3878064          DOI： 10.1158/2159-8290.CD-13-0790

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  8 in total

Review 1.  Computational drug repositioning: from data to therapeutics.

Authors:  M R Hurle; L Yang; Q Xie; D K Rajpal; P Sanseau; P Agarwal
Journal:  Clin Pharmacol Ther       Date:  2013-01-15       Impact factor: 6.875

2.  A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

Authors:  Nadine S Jahchan; Joel T Dudley; Pawel K Mazur; Natasha Flores; Dian Yang; Alec Palmerton; Anne-Flore Zmoos; Dedeepya Vaka; Kim Q T Tran; Margaret Zhou; Karolina Krasinska; Jonathan W Riess; Joel W Neal; Purvesh Khatri; Kwon S Park; Atul J Butte; Julien Sage
Journal:  Cancer Discov       Date:  2013-09-26       Impact factor: 39.397

3.  Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Authors:  Marina Sirota; Joel T Dudley; Jeewon Kim; Annie P Chiang; Alex A Morgan; Alejandro Sweet-Cordero; Julien Sage; Atul J Butte
Journal:  Sci Transl Med       Date:  2011-08-17       Impact factor: 17.956

4.  Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.

Authors:  Joel T Dudley; Marina Sirota; Mohan Shenoy; Reetesh K Pai; Silke Roedder; Annie P Chiang; Alex A Morgan; Minnie M Sarwal; Pankaj Jay Pasricha; Atul J Butte
Journal:  Sci Transl Med       Date:  2011-08-17       Impact factor: 17.956

5.  Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Authors:  Lauren Averett Byers; Jing Wang; Monique B Nilsson; Junya Fujimoto; Pierre Saintigny; John Yordy; Uma Giri; Michael Peyton; You Hong Fan; Lixia Diao; Fatemeh Masrorpour; Li Shen; Wenbin Liu; Boris Duchemann; Praveen Tumula; Vikas Bhardwaj; James Welsh; Stephanie Weber; Bonnie S Glisson; Neda Kalhor; Ignacio I Wistuba; Luc Girard; Scott M Lippman; Gordon B Mills; Kevin R Coombes; John N Weinstein; John D Minna; John V Heymach
Journal:  Cancer Discov       Date:  2012-09-06       Impact factor: 39.397

6.  Perspective: Opportunities in recalcitrant, rare and neglected tumors.

Authors:  Beverly A Teicher
Journal:  Oncol Rep       Date:  2013-07-02       Impact factor: 3.906

7.  The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Authors:  Jordi Barretina; Giordano Caponigro; Nicolas Stransky; Kavitha Venkatesan; Adam A Margolin; Sungjoon Kim; Christopher J Wilson; Joseph Lehár; Gregory V Kryukov; Dmitriy Sonkin; Anupama Reddy; Manway Liu; Lauren Murray; Michael F Berger; John E Monahan; Paula Morais; Jodi Meltzer; Adam Korejwa; Judit Jané-Valbuena; Felipa A Mapa; Joseph Thibault; Eva Bric-Furlong; Pichai Raman; Aaron Shipway; Ingo H Engels; Jill Cheng; Guoying K Yu; Jianjun Yu; Peter Aspesi; Melanie de Silva; Kalpana Jagtap; Michael D Jones; Li Wang; Charles Hatton; Emanuele Palescandolo; Supriya Gupta; Scott Mahan; Carrie Sougnez; Robert C Onofrio; Ted Liefeld; Laura MacConaill; Wendy Winckler; Michael Reich; Nanxin Li; Jill P Mesirov; Stacey B Gabriel; Gad Getz; Kristin Ardlie; Vivien Chan; Vic E Myer; Barbara L Weber; Jeff Porter; Markus Warmuth; Peter Finan; Jennifer L Harris; Matthew Meyerson; Todd R Golub; Michael P Morrissey; William R Sellers; Robert Schlegel; Levi A Garraway
Journal:  Nature       Date:  2012-03-28       Impact factor: 49.962

8.  TCPA: a resource for cancer functional proteomics data.

Authors:  Jun Li; Yiling Lu; Rehan Akbani; Zhenlin Ju; Paul L Roebuck; Wenbin Liu; Ji-Yeon Yang; Bradley M Broom; Roeland G W Verhaak; David W Kane; Chris Wakefield; John N Weinstein; Gordon B Mills; Han Liang
Journal:  Nat Methods       Date:  2013-09-15       Impact factor: 28.547
  8 in total
  6 in total

Review 1.  Small cell lung cancer: will recent progress lead to improved outcomes?

Authors:  M Catherine Pietanza; Lauren Averett Byers; John D Minna; Charles M Rudin
Journal:  Clin Cancer Res       Date:  2015-05-15       Impact factor: 12.531

Review 2.  Small cell lung cancer: where do we go from here?

Authors:  Lauren Averett Byers; Charles M Rudin
Journal:  Cancer       Date:  2014-10-21       Impact factor: 6.860

3.  Exploiting drug repositioning and the brain microenvironment to treat brain metastases.

Authors:  Robert S Kerbel
Journal:  Neuro Oncol       Date:  2016-01-31       Impact factor: 12.300

4.  Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.

Authors:  Jin-Yi Liu; Wei-Qi Fu; Xiang-Jin Zheng; Wan Li; Li-Wen Ren; Jin-Hua Wang; Cui Yang; Guan-Hua Du
Journal:  Acta Pharmacol Sin       Date:  2020-05-25       Impact factor: 6.150

5.  Impact of tricyclic antidepressants, selective serotonin reuptake inhibitors, and other antidepressants on overall survival of patients with advanced lung cancer from 2004 to 2014: University of Cincinnati experience.

Authors:  Nagla Fawzy Abdel Karim; Rammey Hassan; Nabeela Iffat Siddiqi; Ihab Eldessouki; Ola Gaber; Mohamed Rahouma; Mohamed Kamel; Mhender Yellu; Shuchi Gulati; Changchun Xie; Mohamed Magdy; Jane Pruemer
Journal:  J Int Med Res       Date:  2019-10-23       Impact factor: 1.671

Review 6.  Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions.

Authors:  Leilei Fu; Wenke Jin; Jiahui Zhang; Lingjuan Zhu; Jia Lu; Yongqi Zhen; Lan Zhang; Liang Ouyang; Bo Liu; Haiyang Yu
Journal:  Acta Pharm Sin B       Date:  2021-09-10       Impact factor: 11.413
  6 in total

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