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Literature DB >> 24326305

A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.

Masha G Savelieff¹, Yuzhong Liu, Russell R P Senthamarai, Kyle J Korshavn, Hyuck Jin Lee, Ayyalusamy Ramamoorthy, Mi Hee Lim.

Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 24326305 PMCID： PMC3999264 DOI： 10.1039/c3cc48473d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

14 in total

1. 2012 Alzheimer's disease facts and figures.

Authors:
Journal: Alzheimers Dement Date: 2012 Impact factor: 21.566

Review 2. The chemistry of Alzheimer's disease.

Authors: Arvi Rauk
Journal: Chem Soc Rev Date: 2009-06-18 Impact factor: 54.564

3. A partially folded structure of amyloid-beta(1-40) in an aqueous environment.

Authors: Subramanian Vivekanandan; Jeffrey R Brender; Shirley Y Lee; Ayyalusamy Ramamoorthy
Journal: Biochem Biophys Res Commun Date: 2011-06-25 Impact factor: 3.575

Review 4. Metal-associated amyloid-β species in Alzheimer's disease.

Authors: Amit S Pithadia; Mi Hee Lim
Journal: Curr Opin Chem Biol Date: 2012-02-25 Impact factor: 8.822

5. Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.

Authors: Jung-Suk Choi; Joseph J Braymer; Ravi P R Nanga; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal: Proc Natl Acad Sci U S A Date: 2010-12-03 Impact factor: 11.205

6. Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide.

Authors: Anuj K Sharma; Stephanie T Pavlova; Jaekwang Kim; Darren Finkelstein; Nicholas J Hawco; Nigam P Rath; Jungsu Kim; Liviu M Mirica
Journal: J Am Chem Soc Date: 2012-04-06 Impact factor: 15.419

7. Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species.

Authors: Suk-Joon Hyung; Alaina S DeToma; Jeffrey R Brender; Sanghyun Lee; Subramanian Vivekanandan; Akiko Kochi; Jung-Suk Choi; Ayyalusamy Ramamoorthy; Brandon T Ruotolo; Mi Hee Lim
Journal: Proc Natl Acad Sci U S A Date: 2013-02-20 Impact factor: 11.205

8. Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.

Authors: Amit S Pithadia; Akiko Kochi; Molly T Soper; Michael W Beck; Yuzhong Liu; Sanghyun Lee; Alaina S DeToma; Brandon T Ruotolo; Mi Hee Lim
Journal: Inorg Chem Date: 2012-11-15 Impact factor: 5.165

Review 9. Untangling amyloid-β, tau, and metals in Alzheimer's disease.

Authors: Masha G Savelieff; Sanghyun Lee; Yuzhong Liu; Mi Hee Lim
Journal: ACS Chem Biol Date: 2013-03-18 Impact factor: 5.100

Review 10. Alzheimer's disease: from pathology to therapeutic approaches.

Authors: Roland Jakob-Roetne; Helmut Jacobsen
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

12 in total

1. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease.

Authors: Hyuck Jin Lee; Kyle J Korshavn; Younwoo Nam; Juhye Kang; Thomas J Paul; Richard A Kerr; Il Seung Youn; Mehmet Ozbil; Kwang S Kim; Brandon T Ruotolo; Rajeev Prabhakar; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal: Chemistry Date: 2017-01-26 Impact factor: 5.236

2. A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms.

Authors: Jeffrey S Derrick; Richard A Kerr; Younwoo Nam; Shin Bi Oh; Hyuck Jin Lee; Kaylin G Earnest; Nayoung Suh; Kristy L Peck; Mehmet Ozbil; Kyle J Korshavn; Ayyalusamy Ramamoorthy; Rajeev Prabhakar; Edward J Merino; Jason Shearer; Joo-Yong Lee; Brandon T Ruotolo; Mi Hee Lim
Journal: J Am Chem Soc Date: 2015-11-17 Impact factor: 15.419

3. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

Authors: Michael W Beck; Jeffrey S Derrick; Jong-Min Suh; Mingeun Kim; Kyle J Korshavn; Richard A Kerr; Woo Jong Cho; Scott D Larsen; Brandon T Ruotolo; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal: ChemMedChem Date: 2017-10-09 Impact factor: 3.466

4. Rational Design of a Cu Chelator That Mitigates Cu-Induced ROS Production by Amyloid Beta.

Authors: Suchitra Mitra; Kallol Talukdar; Pallavi Prasad; Sandeep K Misra; Shabana Khan; Joshua S Sharp; Jonah W Jurss; Saumen Chakraborty
Journal: Chembiochem Date: 2021-12-30 Impact factor: 3.461

5. Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.

Authors: Xiongwei Dong; Zhe Zhang; Dan Zhao; Yaojing Liu; Yan Meng; Yong Zhang; Dan Zhang; Changlin Liu
Journal: Sci Rep Date: 2015-09-09 Impact factor: 4.379

6. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease.

Authors: Michael W Beck; Shin Bi Oh; Richard A Kerr; Hyuck Jin Lee; So Hee Kim; Sujeong Kim; Milim Jang; Brandon T Ruotolo; Joo-Yong Lee; Mi Hee Lim
Journal: Chem Sci Date: 2015-01-27 Impact factor: 9.825