Literature DB >> 22404854

2012 Alzheimer's disease facts and figures.

.   

Abstract

This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD). Topics addressed include incidence, prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society. The report also explores issues that arise when people with AD and other dementias live alone. The characteristics, risks, and unmet needs of this population are described. An estimated 5.4 million Americans have AD, including approximately 200,000 age <65 years who comprise the younger-onset AD population. Over the coming decades, the aging of the baby boom generation is projected to result in an additional 10 million people with AD. Today, someone in America develops AD every 68 seconds. By 2050, there is expected to be one new case of AD every 33 seconds, or nearly a million new cases per year, and AD prevalence is projected to be 11 million to 16 million. Dramatic increases in the number of "oldest-old" (those age ≥85 years) across all racial and ethnic groups are expected to contribute to the increased prevalence of AD. AD is the sixth leading cause of death in the United States and the fifth leading cause of death in Americans age ≥65 years. Although the proportions of deaths due to other major causes of death have decreased in the last several years, the proportion due to AD has risen significantly. Between 2000 and 2008, the proportion of deaths due to heart disease, stroke, and prostate cancer decreased by 13%, 20%, and 8%, respectively, whereas the proportion due to AD increased by 66%. In 2011, more than 15 million family members and other unpaid caregivers provided an estimated 17.4 billion hours of care to people with AD and other dementias, a contribution valued at more than $210 billion. Medicare payments for services to beneficiaries age ≥65 years with AD and other dementias are three times as great as payments for beneficiaries without these conditions, and Medicaid payments are 19 times as great. In 2012, payments for health care, long-term care, and hospice services for people age ≥65 years with AD and other dementias are expected to be $200 billion (not including the contributions of unpaid caregivers). An estimated 800,000 people with AD (one in seven) live alone, and up to half of them do not have an identifiable caregiver. People with dementia who live alone are exposed to risks that exceed the risks encountered by people with dementia who live with others, including inadequate self-care, malnutrition, untreated medical conditions, falls, wandering from home unattended, and accidental deaths. Copyright Â
© 2012 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Entities:  

Mesh:

Year:  2012        PMID: 22404854     DOI: 10.1016/j.jalz.2012.02.001

Source DB:  PubMed          Journal:  Alzheimers Dement        ISSN: 1552-5260            Impact factor:   21.566


  345 in total

1.  Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.

Authors:  Santiago V Salazar; Timothy O Cox; Suho Lee; A Harrison Brody; Annabel S Chyung; Laura T Haas; Stephen M Strittmatter
Journal:  J Neurosci       Date:  2018-12-05       Impact factor: 6.167

Review 2.  Alzheimer's silent partner: cerebral amyloid angiopathy.

Authors:  Tanya L Cupino; Matthew K Zabel
Journal:  Transl Stroke Res       Date:  2013-11-19       Impact factor: 6.829

3.  A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.

Authors:  Masha G Savelieff; Yuzhong Liu; Russell R P Senthamarai; Kyle J Korshavn; Hyuck Jin Lee; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal:  Chem Commun (Camb)       Date:  2013-12-10       Impact factor: 6.222

4.  The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study.

Authors:  Laura F Defina; Benjamin L Willis; Nina B Radford; Ang Gao; David Leonard; William L Haskell; Myron F Weiner; Jarett D Berry
Journal:  Ann Intern Med       Date:  2013-02-05       Impact factor: 25.391

5.  Vascular risk and FDDNP-PET influence cognitive performance.

Authors:  David A Merrill; Prabha Siddarth; Vladimir Kepe; Pushpa V Raja; Nathan Saito; Linda M Ercoli; Karen J Miller; Helen Lavretsky; Susan Y Bookheimer; Jorge R Barrio; Gary W Small
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

Review 6.  Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer's disease.

Authors:  Stephanie L Leal; Michael A Yassa
Journal:  Ageing Res Rev       Date:  2013-02-04       Impact factor: 10.895

7.  Cross-sectional associations of oral health measures with cognitive function in late middle-aged adults: a community-based study.

Authors:  Supawadee Naorungroj; Victor J Schoenbach; James Beck; Thomas H Mosley; Rebecca F Gottesman; Alvaro Alonso; Gerardo Heiss; Gary D Slade
Journal:  J Am Dent Assoc       Date:  2013-12       Impact factor: 3.634

8.  Collaborative care management reduces disparities in dementia care quality for caregivers with less education.

Authors:  Arleen F Brown; Stefanie D Vassar; Karen I Connor; Barbara G Vickrey
Journal:  J Am Geriatr Soc       Date:  2013-01-15       Impact factor: 5.562

9.  Why are spousal caregivers more prevalent than nonspousal caregivers as study partners in AD dementia clinical trials?

Authors:  Mark S Cary; Jonathan D Rubright; Joshua D Grill; Jason Karlawish
Journal:  Alzheimer Dis Assoc Disord       Date:  2015 Jan-Mar       Impact factor: 2.703

10.  Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.

Authors:  Lap Ho; Mario G Ferruzzi; Elsa M Janle; Jun Wang; Bing Gong; Tzu-Ying Chen; Jessica Lobo; Bruce Cooper; Qing Li Wu; Stephen T Talcott; Susan S Percival; James E Simon; Giulio Maria Pasinetti
Journal:  FASEB J       Date:  2012-10-24       Impact factor: 5.191

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.