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Literature DB >> 2432150

Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.

M A Behlke, T J Henkel, S J Anderson, N C Lan, L Hood, V L Braciale, T J Braciale, D Y Loh.

Abstract

A series of murine T lymphocyte clones were examined for reactivity with the KJ16-133 and F23.1 mAbs. Clones that were KJ16-133+,F23.1+ and KJ16-133-,F23.1+ were identified, but no KJ16-133+,F23.1- clones were observed. Within our panel of clones, therefore, the KJ16-133 antibody identifies a subset of F23.1+ cells. All F23.1+ clones examined express members of the V beta 8 subfamily of beta chain variable region genes; clones expressing V beta 8.1 or V beta 8.2 reacted with both KJ16-133 and F23.1, while clones expressing V beta 8.3 reacted only with F23.1. Thus, the differential reactivity of the KJ16-133 and F23.1 antibodies with cloned T cells correlates with the V beta gene expression of each clone. Reactivity with these antibodies should therefore be of utility for predicting the V beta gene expression in some T cell clones.

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Year: 1987 PMID： 2432150 PMCID： PMC2188246 DOI： 10.1084/jem.165.1.257

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

13 in total

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24 in total

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Journal: Immunology Date: 1994-12 Impact factor: 7.397