Literature DB >> 2427069

Functional analysis of the effect of monoclonal antibodies on monkey liver phenylalanine hydroxylase.

I G Jennings, R G Russell, W L Armarego, R G Cotton.   

Abstract

An analysis of the effect of eleven monoclonal antibodies on the functional characteristics of monkey liver phenylalanine hydroxylase is presented. These eleven antibodies have been found to react with eight distinct regions on the phenylalanine hydroxylase protein. PH1 antibody inhibits enzyme activity, is dependent on phenylalanine for its binding, and appears to be related to structural changes occurring during phenylalanine activation of the enzyme activity. PH2 and PH3 antibodies stimulate enzyme activity, their binding is inhibited by lysolecithin and this group apparently is recognizing structures involved in lysolecithin activation of the enzyme activity. PH5, PH10, PH12 and PH6 recognise sites on phenylalanine hydroxylase affected by lysolecithin activation.

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Year:  1986        PMID： 2427069      PMCID： PMC1146659          DOI： 10.1042/bj2350133

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors:  J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

2.  Kidney phenylalanine hydroxylase from man and rat. Comparison with the liver enzyme.

Authors:  J E Ayling; W D Pirson; J M al-Janabi; G D Helfand
Journal:  Biochemistry       Date:  1974-01-01       Impact factor: 3.162

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Genetics of the mammalian phenylalanine hydroxylase system. II. Immunological and two-dimensional gel electrophoretic studies of phenylalanine hydroxylase in cultured normal and mutant rat hepatoma cells.

Authors:  K H Choo; R G Cotton
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890

5.  Phenylalanine hydroxylase of Macaca irus A simple purification by affinity chromatography.

Authors:  R G Cotton; P J Grattan
Journal:  Eur J Biochem       Date:  1975-12-15

6.  The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties.

Authors:  J P Abita; M Parniak; S Kaufman
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157

7.  Substrate activation of phenylalanine hydroxylase. A kinetic characterization.

Authors:  R Shiman; D W Gray
Journal:  J Biol Chem       Date:  1980-05-25       Impact factor: 5.157

8.  Isolation of phenylalanine hydroxylase-stimulating monoclonal antibody by rat-myeloma--rat-spleen-cell fusion.

Authors:  K H Choo; J Myer; R G Cotton; J Camakaris; D M Danks
Journal:  Biochem J       Date:  1980-11-01       Impact factor: 3.857

9.  Amino acid sequence at the phosphorylated site of rat liver phenylalanine hydroxylase and phosphorylation of a corresponding synthetic peptide.

Authors:  M Wretborn; E Humble; U Ragnarsson; L Engström
Journal:  Biochem Biophys Res Commun       Date:  1980-03-28       Impact factor: 3.575

10.  In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation.

Authors:  J P Abita; S Milstien; N Chang; S Kaufman
Journal:  J Biol Chem       Date:  1976-09-10       Impact factor: 5.157
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  10 in total

1.  Experimental determination of the phosphorylation state of phenylalanine hydroxylase.

Authors:  A K Green; R G Cotton; I Jennings; M J Fisher
Journal:  Biochem J       Date:  1990-01-15       Impact factor: 3.857

2.  A monoclonal antibody to aromatic amino acid hydroxylases. Identification of the epitope.

Authors:  R G Cotton; W McAdam; I Jennings; F J Morgan
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

3.  Peptide analysis of collagen produced from cDNA by transcription and translation in vitro.

Authors:  J F Bateman; S Lamande; D Chan; W G Cole
Journal:  Biochem J       Date:  1987-07-15       Impact factor: 3.857

Review 4.  Structure and function of the aromatic amino acid hydroxylases.

Authors:  S E Hufton; I G Jennings; R G Cotton
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857

5.  Paraventricular hypothalamic nucleus: axonal projections to the brainstem.

Authors:  Joel C Geerling; Jung-Won Shin; Peter C Chimenti; Arthur D Loewy
Journal:  J Comp Neurol       Date:  2010-05-01       Impact factor: 3.215

6.  Inputs to the ventrolateral bed nucleus of the stria terminalis.

Authors:  Jung-Won Shin; Joel C Geerling; Arthur D Loewy
Journal:  J Comp Neurol       Date:  2008-12-10       Impact factor: 3.215

7.  Interaction with a monoclonal antibody alters the expression of co-operativity by phenylalanine hydroxylase from rat liver.

Authors:  M A Parniak; I G Jennings; R G Cotton
Journal:  Biochem J       Date:  1989-01-15       Impact factor: 3.857

8.  5-HT neurons of the area postrema become c-Fos-activated after increases in plasma sodium levels and transmit interoceptive information to the nucleus accumbens.

Authors:  Rebecca L Miller; Arthur D Loewy
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2014-03-05       Impact factor: 3.619

9.  A monoclonal antibody to the phosphorylated form of phenylalanine hydroxylase. Definition of the phosphopeptide epitope.

Authors:  S C Smith; W J McAdam; B E Kemp; F J Morgan; R G Cotton
Journal:  Biochem J       Date:  1987-06-15       Impact factor: 3.857

10.  Immunological detection of phenylalanine hydroxylase protein in Drosophila melanogaster.

Authors:  F J Silva; Y Bel; L M Botella; R G Cotton; J Ferré
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857
  10 in total

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