Literature DB >> 7236218

Isolation of phenylalanine hydroxylase-stimulating monoclonal antibody by rat-myeloma--rat-spleen-cell fusion.

K H Choo, J Myer, R G Cotton, J Camakaris, D M Danks.   

Abstract

A monoclonal antibody directed against monkey liver phenylalanine hydroxylase was produced by using a rat-myeloma--rat-spleen-cell-fusion system. This antibody showed the interesting property of increasing mammalian phenylalanine hydroxylase activity more than 2-fold. Perhaps monoclonal antibodies with this effect on other enzyme or proteins could be developed.

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Year:  1980        PMID： 7236218      PMCID： PMC1162262          DOI： 10.1042/bj1910665

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Virus precursor shedding from mammary tumour cells.

Authors:  A J McClelland
Journal:  Nature       Date:  1979-01-04       Impact factor: 49.962

3.  Letter: Fusion of two immunoglobulin-producing myeloma cells.

Authors:  R G Cotton; C Milstein
Journal:  Nature       Date:  1973-07-06       Impact factor: 49.962

4.  Nomenclature for G-bands in rat chromosomes.

Authors:  G Levan
Journal:  Hereditas       Date:  1974       Impact factor: 3.271

5.  Purification and characterization of phenylalanine hydroxylase-stimulating protein from rat liver.

Authors:  C Y Huang; E E Max; S Kaufman
Journal:  J Biol Chem       Date:  1973-06-25       Impact factor: 5.157

6.  Antibodies to major histocompatibility antigens produced by hybrid cell lines.

Authors:  G Galfre; S C Howe; C Milstein; G W Butcher; J C Howard
Journal:  Nature       Date:  1977-04-07       Impact factor: 49.962

7.  Genetics of the mammalian phenylalanine hydroxylase system. II. Immunological and two-dimensional gel electrophoretic studies of phenylalanine hydroxylase in cultured normal and mutant rat hepatoma cells.

Authors:  K H Choo; R G Cotton
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890

8.  Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria.

Authors:  K H Choo; R G Cotton; D M Danks; I G Jennings
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857
  8 in total
  3 in total

1.  Functional analysis of the effect of monoclonal antibodies on monkey liver phenylalanine hydroxylase.

Authors:  I G Jennings; R G Russell; W L Armarego; R G Cotton
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857

2.  Purification of human adult and foetal intestinal alkaline phosphatases by monoclonal antibody immunoaffinity chromatography.

Authors:  J Vockley; H Harris
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

3.  Comparative studies of four monoclonal antibodies to phenylalanine hydroxylase exhibiting different properties with respect to substrate-dependence, species-specificity and a range of effects on enzyme activity.

Authors:  K H Choo; I G Jennings; R G Cotton
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857
  3 in total

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