Literature DB >> 24251838

Antimicrobial and antiseptic strategies in wound management.

Georg Daeschlein1.   

Abstract

Wounds, especially chronic wounds, represent a global problem costing millions of dollars per year in developed countries and are characterised by microbial complications including local or overt infection, delayed healing and spread of multiresistant germs. Therefore, antimicrobial wound management is a major challenge that continues to require new solutions against microbes and their biofilms. As systemic antibiotics can barely penetrate into wound biofilms and topically applied ones can easily lead to sensitisation, antisepsis is the method of choice to treat germs in wounds. This brief review discusses the role of antiseptics in reducing bioburden in chronic wounds. Balancing antimicrobial potency and tolerability of antiseptic procedures is critical in wound therapy. However, antiseptics alone may not be able to achieve wound healing without addressing other factors regarding the patient's general health or the wound's physical environment. Although the precise role of bioburden in chronic wounds remains to be evaluated, planktonic as well as biofilm-bound microbes are indications for antiseptic intervention. Octenidine dihydrochloride and polyhexanide are the most effective, as well as best tolerated, antiseptics in wound management today, and new strategies to reduce bacterial wound burden and support the body's immune response are being developed.
© 2013 The Author. International Wound Journal © 2013 John Wiley & Sons Ltd and Medicalhelplines.com Inc.

Entities:  

Keywords:  Antimicrobial; Antiseptics; Bioburden; Biofilms; Chronic wounds

Mesh:

Substances:

Year:  2013        PMID: 24251838      PMCID: PMC7950476          DOI: 10.1111/iwj.12175

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  19 in total

1.  Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial.

Authors:  Chantal M Mouës; Margreet C Vos; Gert-Jan C M van den Bemd; Theo Stijnen; Steven E R Hovius
Journal:  Wound Repair Regen       Date:  2004 Jan-Feb       Impact factor: 3.617

2.  Aerobic and anaerobic bacteriology of wounds and cutaneous abscesses.

Authors:  I Brook; E H Frazier
Journal:  Arch Surg       Date:  1990-11

3.  Bacterial biofilms in wounds.

Authors:  Vijay A Singh; Adrian Barbul
Journal:  Wound Repair Regen       Date:  2008 Jan-Feb       Impact factor: 3.617

Review 4.  Wound infection. A failure of wound healing caused by an imbalance of bacteria.

Authors:  M C Robson
Journal:  Surg Clin North Am       Date:  1997-06       Impact factor: 2.741

5.  Quantitative assessment of bacterial contamination of open wounds by a slide techniue.

Authors:  J P Heggers; M C Robson; E T Doran
Journal:  Trans R Soc Trop Med Hyg       Date:  1969       Impact factor: 2.184

6.  Approach to diagnosing lower extremity ulcers.

Authors:  Eri Fukaya; David J Margolis
Journal:  Dermatol Ther       Date:  2013 May-Jun       Impact factor: 2.851

7.  First experiences with negative pressure wound therapy and instillation in the treatment of infected orthopaedic implants: a clinical observational study.

Authors:  Burkhard Lehner; Wim Fleischmann; Rolf Becker; Gerrolt N Jukema
Journal:  Int Orthop       Date:  2011-05-17       Impact factor: 3.075

8.  In vitro antibacterial activity of Lucilia sericata maggot secretions.

Authors:  G Daeschlein; K Y Mumcuoglu; O Assadian; B Hoffmeister; A Kramer
Journal:  Skin Pharmacol Physiol       Date:  2006-12-13       Impact factor: 3.479

9.  Influence of the antiseptic agents polyhexanide and octenidine on FL cells and on healing of experimental superficial aseptic wounds in piglets. A double-blind, randomised, stratified, controlled, parallel-group study.

Authors:  A Kramer; B Roth; G Müller; P Rudolph; N Klöcker
Journal:  Skin Pharmacol Physiol       Date:  2004 May-Jun       Impact factor: 3.479

10.  Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial.

Authors:  Peter A Blume; Jodi Walters; Wyatt Payne; Jose Ayala; John Lantis
Journal:  Diabetes Care       Date:  2007-12-27       Impact factor: 19.112

View more
  27 in total

1.  Pericardial tissue for cardiovascular application: an in-vitro evaluation of established and advanced production processes.

Authors:  L Grefen; F König; M Grab; C Hagl; N Thierfelder
Journal:  J Mater Sci Mater Med       Date:  2018-11-03       Impact factor: 3.896

Review 2.  Antimicrobial and antiseptic strategies in wound management.

Authors:  Georg Daeschlein
Journal:  Int Wound J       Date:  2013-12       Impact factor: 3.315

Review 3.  Recent accomplishments in wound healing.

Authors:  Elizabeth J Mudge
Journal:  Int Wound J       Date:  2014-02-21       Impact factor: 3.315

4.  Feedback-controlled photolytic gas phase nitric oxide delivery from S-nitrosothiol-doped silicone rubber films.

Authors:  Gergely Lautner; Orsolya Lautner-Csorba; Blake Stringer; Mark E Meyerhoff; Steven P Schwendeman
Journal:  J Control Release       Date:  2019-11-25       Impact factor: 9.776

5.  Topical simvastatin promotes healing of Staphylococcus aureus-contaminated cutaneous wounds.

Authors:  Chia-Chi Wang; Po-Wei Yang; Sheau-Fang Yang; Kun-Pin Hsieh; Sung-Pin Tseng; Ying-Chi Lin
Journal:  Int Wound J       Date:  2015-03-08       Impact factor: 3.315

6.  Dermal fibroblast cells interactions with single and triple bacterial-species biofilms.

Authors:  Betül Çelebi-Saltik; Didem Kart
Journal:  Mol Biol Rep       Date:  2021-05-19       Impact factor: 2.316

7.  The Effect of Antiseptics on Adipose-Derived Stem Cells.

Authors:  Bong-Sung Kim; Veronica Ott; Arne Hendrick Boecker; Jan-Philipp Stromps; Nora Emilie Paul; Ziyad Alharbi; Ercan Cakmak; Jürgen Bernhagen; Richard Bucala; Norbert Pallua
Journal:  Plast Reconstr Surg       Date:  2017-03       Impact factor: 4.730

8.  Low-frequency ultrasound increase effectiveness of silver nanoparticles in a purulent wound model.

Authors:  Petro Myronov; Volodymyr Bugaiov; Viktoriia Holubnycha; Vladyslav Sikora; Volodymyr Deineka; Mykola Lyndin; Anatoliy Opanasyuk; Anatoliy Romaniuk; Maksym Pogorielov
Journal:  Biomed Eng Lett       Date:  2020-10-17

9.  In vitro Activity of Antimicrobial Wound Dressings on P. aeruginosa Wound Biofilm.

Authors:  Ewa Klara Stuermer; Isabell Plattfaut; Michael Dietrich; Florian Brill; Andreas Kampe; Vanessa Wiencke; Anna Ulatowski; Maria Geffken; Julian-Dario Rembe; Ella Alexandrovna Naumova; Sebastian Eike Debus; Ralf Smeets
Journal:  Front Microbiol       Date:  2021-05-14       Impact factor: 5.640

Review 10.  Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects.

Authors:  Kaushita Banerjee; Radha Madhyastha; Yuichi Nakajima; Masugi Maruyama; Harishkumar Madhyastha
Journal:  Int J Mol Sci       Date:  2021-04-29       Impact factor: 5.923

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.