PURPOSE: Infections associated with orthopaedic implants remain a serious complication. The main objective in acute infection control is component retention, whereas this option is usually not considered for chronic infections. METHODS: This multi-centre prospective, non-randomised observational study investigated one possible treatment option for implant retention in combination with negative pressure wound therapy with instillation (NPWTi). Thirty-two patients with an infected orthopaedic implant were analysed. Twenty-two patients had an acute infection (< 8 weeks after implantation) and ten patients had a chronic infection (> 8 weeks and < 36 weeks after implant placement). Polyhexanide was used as the instillation solution in 31 of the 32 cases. RESULTS: Nineteen patients (86.4%) with an acute infection and eight patients (80%) with a chronic infection retained their implant at 4-6 months follow-up after treatment. CONCLUSIONS: Our study showed that NPWTi can be used as adjunctive therapy for salvage of acutely infected orthopaedic implants and may even be considered for early chronically infected implants.
PURPOSE: Infections associated with orthopaedic implants remain a serious complication. The main objective in acute infection control is component retention, whereas this option is usually not considered for chronic infections. METHODS: This multi-centre prospective, non-randomised observational study investigated one possible treatment option for implant retention in combination with negative pressure wound therapy with instillation (NPWTi). Thirty-two patients with an infected orthopaedic implant were analysed. Twenty-two patients had an acute infection (< 8 weeks after implantation) and ten patients had a chronic infection (> 8 weeks and < 36 weeks after implant placement). Polyhexanide was used as the instillation solution in 31 of the 32 cases. RESULTS: Nineteen patients (86.4%) with an acute infection and eight patients (80%) with a chronic infection retained their implant at 4-6 months follow-up after treatment. CONCLUSIONS: Our study showed that NPWTi can be used as adjunctive therapy for salvage of acutely infected orthopaedic implants and may even be considered for early chronically infected implants.
Authors: J Cobo; L Garcia San Miguel; G Euba; D Rodríguez; J M García-Lechuz; M Riera; L Falgueras; J Palomino; N Benito; M D del Toro; C Pigrau; J Ariza Journal: Clin Microbiol Infect Date: 2010-07-30 Impact factor: 8.067
Authors: James D Whitehouse; N Deborah Friedman; Kathryn B Kirkland; William J Richardson; Daniel J Sexton Journal: Infect Control Hosp Epidemiol Date: 2002-04 Impact factor: 3.254
Authors: Carl Deirmengian; Jordan Greenbaum; John Stern; Michael Braffman; Paul A Lotke; Robert E Booth; Jess H Lonner Journal: Clin Orthop Relat Res Date: 2003-11 Impact factor: 4.176
Authors: Christian Willy; Catharina Scheuermann-Poley; Marcus Stichling; Thomas von Stein; Axel Kramer Journal: Unfallchirurg Date: 2017-07 Impact factor: 1.000
Authors: Julie M West; Sumanas W Jordan; Ehud Mendel; Safdar N Khan; Rajiv Y Chandawarkar; Ian L Valerio Journal: Adv Wound Care (New Rochelle) Date: 2018-10-11 Impact factor: 4.730
Authors: Ingo Ludolph; Frederik W Fried; Katharina Kneppe; Andreas Arkudas; Marweh Schmitz; Raymund E Horch Journal: Int Wound J Date: 2018-07-04 Impact factor: 3.315