Literature DB >> 24247110

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.

Mi-Kyung Lee1, Angel Bottini, Meehyein Kim, Michael F Bardaro, Ziming Zhang, Maurizio Pellecchia, Byong-Seok Choi, Gabriele Varani.   

Abstract

Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.

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Year:  2013        PMID： 24247110      PMCID： PMC3894927          DOI： 10.1039/c3cc46973e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  16 in total

1.  Structural features of an influenza virus promoter and their implications for viral RNA synthesis.

Authors:  S H Bae; H K Cheong; J H Lee; C Cheong; M Kainosho; B S Choi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-11       Impact factor: 11.205

2.  A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase.

Authors:  Mi-Kyung Lee; Sung-Hun Bae; Chin-Ju Park; Hae-Kap Cheong; Chaejoon Cheong; Byong-Seok Choi
Journal:  Nucleic Acids Res       Date:  2003-02-15       Impact factor: 16.971

3.  A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells.

Authors:  D Schols; R Pauwels; F Vanlangendonck; J Balzarini; E De Clercq
Journal:  J Immunol Methods       Date:  1988-11-10       Impact factor: 2.303

4.  Structure of the ribonucleoprotein of influenza virus.

Authors:  R W Compans; J Content; P H Duesberg
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

5.  The influenza virus panhandle is involved in the initiation of transcription.

Authors:  E Fodor; D C Pritlove; G G Brownlee
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

6.  Photochemical cross-linking of influenza A polymerase to its virion RNA promoter defines a polymerase binding site at residues 9 to 12 of the promoter.

Authors:  E Fodor; B L Seong; G G Brownlee
Journal:  J Gen Virol       Date:  1993-07       Impact factor: 3.891

7.  Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5' ends of the viral RNAs.

Authors:  L S Tiley; M Hagen; J T Matthews; M Krystal
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

8.  The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter.

Authors:  George G Brownlee; Jane L Sharps
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

9.  The 3' and 5'-terminal sequences of influenza A, B and C virus RNA segments are highly conserved and show partial inverted complementarity.

Authors:  U Desselberger; V R Racaniello; J J Zazra; P Palese
Journal:  Gene       Date:  1980-02       Impact factor: 3.688

10.  The structure of a biologically active influenza virus ribonucleoprotein complex.

Authors:  Rocío Coloma; José M Valpuesta; Rocío Arranz; José L Carrascosa; Juan Ortín; Jaime Martín-Benito
Journal:  PLoS Pathog       Date:  2009-06-26       Impact factor: 6.823
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  21 in total

Review 1.  Structure based approaches for targeting non-coding RNAs with small molecules.

Authors:  Matthew D Shortridge; Gabriele Varani
Journal:  Curr Opin Struct Biol       Date:  2015-02-16       Impact factor: 6.809

Review 2.  Synthetic small-molecule RNA ligands: future prospects as therapeutic agents.

Authors:  A Di Giorgio; M Duca
Journal:  Medchemcomm       Date:  2019-04-30       Impact factor: 3.597

3.  Targeting Influenza A Virus RNA Promoter.

Authors:  Angel Bottini; Surya K De; Bainan Wu; Changyan Tang; Gabriele Varani; Maurizio Pellecchia
Journal:  Chem Biol Drug Des       Date:  2015-03-13       Impact factor: 2.817

4.  SILCS-RNA: Toward a Structure-Based Drug Design Approach for Targeting RNAs with Small Molecules.

Authors:  Abhishek A Kognole; Anthony Hazel; Alexander D MacKerell
Journal:  J Chem Theory Comput       Date:  2022-08-01       Impact factor: 6.578

5.  Efficient NMR Screening Approach to Discover Small Molecule Fragments Binding Structured RNA.

Authors:  Matthew D Shortridge; Gabriele Varani
Journal:  ACS Med Chem Lett       Date:  2021-07-13       Impact factor: 4.632

Review 6.  Advances in discovering small molecules to probe protein function in a systems context.

Authors:  Shelby K Doyle; Marius S Pop; Helen L Evans; Angela N Koehler
Journal:  Curr Opin Chem Biol       Date:  2015-11-23       Impact factor: 8.822

7.  RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges.

Authors:  Ai-Ming Yu; Young Hee Choi; Mei-Juan Tu
Journal:  Pharmacol Rev       Date:  2020-10       Impact factor: 25.468

8.  Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.

Authors:  Sai Pradeep Velagapudi; Matthew G Costales; Balayeshwanth R Vummidi; Yoshio Nakai; Alicia J Angelbello; Tuan Tran; Hafeez S Haniff; Yasumasa Matsumoto; Zi Fu Wang; Arnab K Chatterjee; Jessica L Childs-Disney; Matthew D Disney
Journal:  Cell Chem Biol       Date:  2018-06-28       Impact factor: 8.116

9.  Structural features of a 3' splice site in influenza a.

Authors:  Jonathan L Chen; Scott D Kennedy; Douglas H Turner
Journal:  Biochemistry       Date:  2015-05-21       Impact factor: 3.162

Review 10.  Target-Directed Approaches for Screening Small Molecules against RNA Targets.

Authors:  Hafeez S Haniff; Laurent Knerr; Jonathan L Chen; Matthew D Disney; Helen L Lightfoot
Journal:  SLAS Discov       Date:  2020-05-18       Impact factor: 3.341
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