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Literature DB >> 24217700

In vitro study of sequential fluconazole and caspofungin treatment against Candida albicans biofilms.

Semanti Sarkar¹, Priya Uppuluri, Christopher G Pierce, Jose L Lopez-Ribot.

Abstract

Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular stress responses induced by high fluconazole concentrations and mediated by Hsp90 and calcineurin play an important role in this phenomenon.

Entities: Chemical Species

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Year: 2013 PMID： 24217700 PMCID： PMC3910858 DOI： 10.1128/AAC.01745-13

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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