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Literature DB >> 12384379

In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies.

Gordon Ramage¹, Kacy VandeWalle, Stefano P Bachmann, Brian L Wickes, José L López-Ribot.

Abstract

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with > or =99% killing at physiological concentrations.

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Year: 2002 PMID： 12384379 PMCID： PMC128738 DOI： 10.1128/AAC.46.11.3634-3636.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

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Authors: R M Donlan
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Review 5. Biofilms of Candida albicans and their associated resistance to antifungal agents.

Authors: G Ramage; B L Wickes; J L Lopez-Ribot
Journal: Am Clin Lab Date: 2001-08

6. Pharmacodynamics of fluconazole, itraconazole, and amphotericin B against Candida albicans.

Authors: D S Burgess; R W Hastings; K K Summers; T C Hardin; M G Rinaldi
Journal: Diagn Microbiol Infect Dis Date: 2000-01 Impact factor: 2.803

7. Rates and extents of antifungal activities of amphotericin B, flucytosine, fluconazole, and voriconazole against Candida lusitaniae determined by microdilution, Etest, and time-kill methods.

Authors: Erika J Ernst; Keiko Yodoi; Ellen E Roling; Michael E Klepser
Journal: Antimicrob Agents Chemother Date: 2002-02 Impact factor: 5.191

8. Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms.

Authors: G Ramage; K Vande Walle; B L Wickes; J L López-Ribot
Journal: Antimicrob Agents Chemother Date: 2001-09 Impact factor: 5.191

9. Single- and multiple-dose pharmacokinetics of caspofungin in healthy men.

Authors: Julie A Stone; Sherry D Holland; Peter J Wickersham; Andrew Sterrett; Michael Schwartz; Cynthia Bonfiglio; Michael Hesney; Gregory A Winchell; Paul J Deutsch; Howard Greenberg; Thomas L Hunt; Scott A Waldman
Journal: Antimicrob Agents Chemother Date: 2002-03 Impact factor: 5.191

10. Characteristics of biofilm formation by Candida albicans.

Authors: G Ramage; K Vandewalle; B L Wickes; J L López-Ribot
Journal: Rev Iberoam Micol Date: 2001-12 Impact factor: 1.044

77 in total

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Journal: Antimicrob Agents Chemother Date: 2011-04-25 Impact factor: 5.191

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3. Effects of antifungal interventions on the outcome of experimental infections with phenotypic switch variants of Cryptococcus neoformans.

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