Literature DB >> 24125862

Epigenetics and cancer metabolism.

Christelle Johnson1, Marc O Warmoes2, Xiling Shen3, Jason W Locasale4.   

Abstract

Cancer cells adapt their metabolism to support proliferation and survival. A hallmark of cancer, this alteration is characterized by dysfunctional metabolic enzymes, changes in nutrient availability, tumor microenvironment and oncogenic mutations. Metabolic rewiring in cancer is tightly connected to changes at the epigenetic level. Enzymes that mediate epigenetic status of cells catalyze posttranslational modifications of DNA and histones and influence metabolic gene expression. These enzymes require metabolites that are used as cofactors and substrates to carry out reactions. This interaction of epigenetics and metabolism constitutes a new avenue of cancer biology and could lead to new insights for the development of anti-cancer therapeutics.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Amino acid metabolism; Cancer; Epigenetics; Glucose flux; Metabolism

Mesh：

Substances：

Year:  2013        PMID： 24125862      PMCID： PMC3984372          DOI： 10.1016/j.canlet.2013.09.043

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  86 in total

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2.  On the origin of cancer cells.

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6.  JmjC-domain-containing proteins and histone demethylation.

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Journal:  Nat Rev Genet       Date:  2006-09       Impact factor: 53.242

Review 7.  When signaling kinases meet histones and histone modifiers in the nucleus.

Authors:  Sung Hee Baek
Journal:  Mol Cell       Date:  2011-05-06       Impact factor: 17.970

8.  Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Authors:  Jason W Locasale; Alexandra R Grassian; Tamar Melman; Costas A Lyssiotis; Katherine R Mattaini; Adam J Bass; Gregory Heffron; Christian M Metallo; Taru Muranen; Hadar Sharfi; Atsuo T Sasaki; Dimitrios Anastasiou; Edouard Mullarky; Natalie I Vokes; Mika Sasaki; Rameen Beroukhim; Gregory Stephanopoulos; Azra H Ligon; Matthew Meyerson; Andrea L Richardson; Lynda Chin; Gerhard Wagner; John M Asara; Joan S Brugge; Lewis C Cantley; Matthew G Vander Heiden
Journal:  Nat Genet       Date:  2011-07-31       Impact factor: 38.330

9.  The consequences of enhanced cell-autonomous glucose metabolism.

Authors:  Jason W Locasale
Journal:  Trends Endocrinol Metab       Date:  2012-08-21       Impact factor: 12.015

10.  Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

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Journal:  Cell       Date:  2011-09-16       Impact factor: 41.582
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Review 1.  Mitostemness.

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Journal:  Cell Cycle       Date:  2018-07-02       Impact factor: 4.534

Review 2.  Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis.

Authors:  Malachi A Blundon; Subhamoy Dasgupta
Journal:  Endocrinology       Date:  2019-08-01       Impact factor: 4.736

Review 3.  Non-metabolic functions of glycolytic enzymes in tumorigenesis.

Authors:  X Yu; S Li
Journal:  Oncogene       Date:  2016-10-31       Impact factor: 9.867

Review 4.  Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

Authors:  R Brooks Robey; Judith Weisz; Nancy B Kuemmerle; Anna C Salzberg; Arthur Berg; Dustin G Brown; Laura Kubik; Roberta Palorini; Fahd Al-Mulla; Rabeah Al-Temaimi; Annamaria Colacci; Chiara Mondello; Jayadev Raju; Jordan Woodrick; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Rabindra Roy; Stefano Forte; Lorenzo Memeo; Hosni K Salem; Amedeo Amedei; Roslida A Hamid; Graeme P Williams; Leroy Lowe; Joel Meyer; Francis L Martin; William H Bisson; Ferdinando Chiaradonna; Elizabeth P Ryan
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

Review 5.  Metabolic control of cancer cell stemness: Lessons from iPS cells.

Authors:  Javier A Menendez
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

6.  Understanding tumor anabolism and patient catabolism in cancer-associated cachexia.

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Review 7.  Metabolic interactions with cancer epigenetics.

Authors:  Xia Gao; Michael A Reid; Mei Kong; Jason W Locasale
Journal:  Mol Aspects Med       Date:  2016-09-09

8.  Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.

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Journal:  Am J Cancer Res       Date:  2016-03-15       Impact factor: 6.166

Review 9.  Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer.

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