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Literature DB >> 27620316

Metabolic interactions with cancer epigenetics.

Xia Gao¹, Michael A Reid², Mei Kong², Jason W Locasale³.

Abstract

Cancer cells have epigenetic alterations that are known to drive cancer progression. The reversibility of the epigenetic posttranslational modifications on chromatin and DNA renders targeting these modifications an attractive means for cancer therapy. Cellular epigenetic status interacts with cell metabolism, and we are now beginning to understand the nature of how this interaction occurs and the biological contexts that mediate its function. Given the tremendous interest in understanding and targeting metabolic reprogramming in cancer, this nexus also provides opportunities for exploring the liabilities of cancers. This review summarizes recent developments in our understanding of the interaction of cancer metabolism and epigenetics.

Entities: Chemical Disease Gene Mutation Species

Keywords: Acetyl-CoA; Methionine; One-carbon metabolism; S-Adenosyl methionine; Serine; α-Ketoglutarate

Mesh：

Substances：
Histones

Year: 2016 PMID： 27620316 PMCID： PMC5344790 DOI： 10.1016/j.mam.2016.09.001

Source DB: PubMed Journal: Mol Aspects Med ISSN： 0098-2997

107 in total

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17 in total

1. Should we consider subcellular compartmentalization of metabolites, and if so, how do we measure them?

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Journal: J Clin Invest Date: 2021-06-15 Impact factor: 14.808