Literature DB >> 24108414

Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.

Jiachen Zi1, Reuben J Peters.   

Abstract

Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).

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Year:  2013        PMID： 24108414      PMCID： PMC3922537          DOI： 10.1039/c3ob41885e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  16 in total

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3.  A modular approach for facile biosynthesis of labdane-related diterpenes.

Authors:  Anthony Cyr; P Ross Wilderman; Mara Determan; Reuben J Peters
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Journal:  FEBS Lett       Date:  2011-10-05       Impact factor: 4.124

5.  Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster.

Authors:  Qiang Wang; Matthew L Hillwig; Kazunori Okada; Kohei Yamazaki; Yisheng Wu; Sivakumar Swaminathan; Hisakazu Yamane; Reuben J Peters
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Review 6.  New developments in the chemistry and biology of the bioactive constituents of Tanshen.

Authors:  Xihong Wang; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2007-01       Impact factor: 12.944

7.  CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice.

Authors:  Qiang Wang; Matthew L Hillwig; Reuben J Peters
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Review 8.  Carnosol: a promising anti-cancer and anti-inflammatory agent.

Authors:  Jeremy J Johnson
Journal:  Cancer Lett       Date:  2011-03-05       Impact factor: 8.679

9.  Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering.

Authors:  Dana Morrone; Luke Lowry; Mara K Determan; David M Hershey; Meimei Xu; Reuben J Peters
Journal:  Appl Microbiol Biotechnol       Date:  2009-09-24       Impact factor: 4.813

Review 10.  Hydrocarbon hydroxylation by cytochrome P450 enzymes.

Authors:  Paul R Ortiz de Montellano
Journal:  Chem Rev       Date:  2010-02-10       Impact factor: 60.622
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  32 in total

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Journal:  Plant J       Date:  2017-12-02       Impact factor: 6.417

2.  Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures.

Authors:  Fainmarinat S Inabuy; Justin T Fischedick; Iris Lange; Michael Hartmann; Narayanan Srividya; Amber N Parrish; Meimei Xu; Reuben J Peters; B Markus Lange
Journal:  Plant Physiol       Date:  2017-07-27       Impact factor: 8.340

3.  Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis.

Authors:  Naoki Kitaoka; Yisheng Wu; Meimei Xu; Reuben J Peters
Journal:  Appl Microbiol Biotechnol       Date:  2015-03-12       Impact factor: 4.813

4.  Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza.

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Journal:  Mol Plant       Date:  2016-03-24       Impact factor: 13.164

5.  Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.

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Journal:  New Phytol       Date:  2015-12-18       Impact factor: 10.151

6.  Functional Diversification of Kaurene Synthase-Like Genes in Isodon rubescens.

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Journal:  Plant Physiol       Date:  2017-04-05       Impact factor: 8.340

Review 7.  The application of synthetic biology to elucidation of plant mono-, sesqui-, and diterpenoid metabolism.

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Journal:  Mol Plant       Date:  2014-12-11       Impact factor: 13.164

Review 8.  Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis.

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Journal:  Curr Opin Plant Biol       Date:  2022-02-20       Impact factor: 7.834

9.  Carnosic acid biosynthesis elucidated by a synthetic biology platform.

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Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-14       Impact factor: 11.205

10.  Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides.

Authors:  René Höfer; Benoît Boachon; Hugues Renault; Carole Gavira; Laurence Miesch; Juliana Iglesias; Jean-François Ginglinger; Lionel Allouche; Michel Miesch; Sebastien Grec; Romain Larbat; Danièle Werck-Reichhart
Journal:  Plant Physiol       Date:  2014-07-31       Impact factor: 8.340
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