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Literature DB >> 24105274

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.

Christoph Plass¹, Stefan M Pfister, Anders M Lindroth, Olga Bogatyrova, Rainer Claus, Peter Lichter.

Abstract

Malignancies are characterized by extensive global reprogramming of epigenetic patterns, including gains or losses in DNA methylation and changes to histone marks. Furthermore, high-resolution genome-sequencing efforts have discovered a wealth of mutations in genes encoding epigenetic regulators that have roles as 'writers', 'readers' or 'editors' of DNA methylation and/or chromatin states. In this Review, we discuss how these mutations have the potential to deregulate hundreds of targeted genes genome wide. Elucidating these networks of epigenetic factors will provide mechanistic understanding of the interplay between genetic and epigenetic alterations, and will inform novel therapeutic strategies.

Entities: Disease

Mesh：

Substances：

Year: 2013 PMID： 24105274 DOI： 10.1038/nrg3554

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

154 in total

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167 in total

Review 1. Epigenetic dysregulation in follicular lymphoma.

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Review 3. High-throughput sequencing offers new insights into 5-hydroxymethylcytosine.

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Review 4. DNA Hypomethylating Drugs in Cancer Therapy.

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Review 5. Function and information content of DNA methylation.

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8. Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.

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