Literature DB >> 26698557

Epigenetic dysregulation in follicular lymphoma.

Shamzah Araf1, Jessica Okosun1, Lola Koniali1, Jude Fitzgibbon1, James Heward1.   

Abstract

The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.

Entities:  

Keywords:  CREBBP; EP300; EZH2; KMT2D; epigenetics; follicular lymphoma; histone acetylation; histone methylation; noncoding RNA

Mesh：

Substances：

Year:  2015        PMID： 26698557      PMCID： PMC4864036          DOI： 10.2217/epi.15.96

Source DB:  PubMed          Journal:  Epigenomics        ISSN： 1750-192X            Impact factor:   4.778


  61 in total

1.  Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Authors:  Christopher J Sneeringer; Margaret Porter Scott; Kevin W Kuntz; Sarah K Knutson; Roy M Pollock; Victoria M Richon; Robert A Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

2.  EZH2 Y641 mutations in follicular lymphoma.

Authors:  C Bödör; C O'Riain; D Wrench; J Matthews; S Iyengar; H Tayyib; M Calaminici; A Clear; S Iqbal; H Quentmeier; H G Drexler; S Montoto; A T Lister; J G Gribben; A Matolcsy; J Fitzgibbon
Journal:  Leukemia       Date:  2011-01-14       Impact factor: 11.528

Review 3.  Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.

Authors:  Rajesh C Rao; Yali Dou
Journal:  Nat Rev Cancer       Date:  2015-06       Impact factor: 60.716

4.  Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.

Authors:  Stéphanie Sungalee; Emilie Mamessier; Ester Morgado; Emilie Grégoire; Philip Z Brohawn; Christopher A Morehouse; Nathalie Jouve; Céline Monvoisin; Cédric Menard; Guilhaume Debroas; Mustapha Faroudi; Violaine Mechin; Jean-Marc Navarro; Charlotte Drevet; Franziska C Eberle; Lionel Chasson; Fannie Baudimont; Stéphane J Mancini; Julie Tellier; Jean-Michel Picquenot; Rachel Kelly; Paolo Vineis; Philippe Ruminy; Bruno Chetaille; Elaine S Jaffe; Claudine Schiff; Jean Hardwigsen; David A Tice; Brandon W Higgs; Karin Tarte; Bertrand Nadel; Sandrine Roulland
Journal:  J Clin Invest       Date:  2014-11-10       Impact factor: 14.808

5.  Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.

Authors:  Michael R Green; Shingo Kihira; Chih Long Liu; Ramesh V Nair; Raheleh Salari; Andrew J Gentles; Jonathan Irish; Henning Stehr; Carolina Vicente-Dueñas; Isabel Romero-Camarero; Isidro Sanchez-Garcia; Sylvia K Plevritis; Daniel A Arber; Serafim Batzoglou; Ronald Levy; Ash A Alizadeh
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-23       Impact factor: 11.205

Review 6.  Common progenitor cells in mature B-cell malignancies: implications for therapy.

Authors:  Michael R Green; Ash A Alizadeh
Journal:  Curr Opin Hematol       Date:  2014-07       Impact factor: 3.284

7.  EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.

Authors:  Wendy Béguelin; Relja Popovic; Matt Teater; Yanwen Jiang; Karen L Bunting; Monica Rosen; Hao Shen; Shao Ning Yang; Ling Wang; Teresa Ezponda; Eva Martinez-Garcia; Haikuo Zhang; Yupeng Zheng; Sharad K Verma; Michael T McCabe; Heidi M Ott; Glenn S Van Aller; Ryan G Kruger; Yan Liu; Charles F McHugh; David W Scott; Young Rock Chung; Neil Kelleher; Rita Shaknovich; Caretha L Creasy; Randy D Gascoyne; Kwok-Kin Wong; Leandro Cerchietti; Ross L Levine; Omar Abdel-Wahab; Jonathan D Licht; Olivier Elemento; Ari M Melnick
Journal:  Cancer Cell       Date:  2013-05-13       Impact factor: 31.743

Review 8.  Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.

Authors:  Christoph Plass; Stefan M Pfister; Anders M Lindroth; Olga Bogatyrova; Rainer Claus; Peter Lichter
Journal:  Nat Rev Genet       Date:  2013-10-09       Impact factor: 53.242

9.  Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Authors:  Laura Pasqualucci; David Dominguez-Sola; Annalisa Chiarenza; Giulia Fabbri; Adina Grunn; Vladimir Trifonov; Lawryn H Kasper; Stephanie Lerach; Hongyan Tang; Jing Ma; Davide Rossi; Amy Chadburn; Vundavalli V Murty; Charles G Mullighan; Gianluca Gaidano; Raul Rabadan; Paul K Brindle; Riccardo Dalla-Favera
Journal:  Nature       Date:  2011-03-10       Impact factor: 49.962

10.  Array-based DNA methylation profiling in follicular lymphoma.

Authors:  C O'Riain; D M O'Shea; Y Yang; R Le Dieu; J G Gribben; K Summers; J Yeboah-Afari; L Bhaw-Rosun; C Fleischmann; C A Mein; T Crook; P Smith; G Kelly; A Rosenwald; G Ott; E Campo; L M Rimsza; E B Smeland; W C Chan; N Johnson; R D Gascoyne; S Reimer; R M Braziel; G W Wright; L M Staudt; T A Lister; J Fitzgibbon
Journal:  Leukemia       Date:  2009-07-09       Impact factor: 11.528
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  6 in total

1.  IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome.

Authors:  Jun Wang; Abu Z Dayem Ullah; Claude Chelala
Journal:  Nucleic Acids Res       Date:  2018-05-04       Impact factor: 16.971

Review 2.  Evolving therapeutic landscape in follicular lymphoma: a look at emerging and investigational therapies.

Authors:  Walter Hanel; Narendranath Epperla
Journal:  J Hematol Oncol       Date:  2021-06-30       Impact factor: 17.388

3.  A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.

Authors:  Lev Litichevskiy; Ryan Peckner; Jennifer G Abelin; Jacob K Asiedu; Amanda L Creech; John F Davis; Desiree Davison; Caitlin M Dunning; Jarrett D Egertson; Shawn Egri; Joshua Gould; Tak Ko; Sarah A Johnson; David L Lahr; Daniel Lam; Zihan Liu; Nicholas J Lyons; Xiaodong Lu; Brendan X MacLean; Alison E Mungenast; Adam Officer; Ted E Natoli; Malvina Papanastasiou; Jinal Patel; Vagisha Sharma; Courtney Toder; Andrew A Tubelli; Jennie Z Young; Steven A Carr; Todd R Golub; Aravind Subramanian; Michael J MacCoss; Li-Huei Tsai; Jacob D Jaffe
Journal:  Cell Syst       Date:  2018-04-11       Impact factor: 10.304

Review 4.  Epigenetics of Indolent Lymphoma and How It Drives Novel Therapeutic Approaches-Focus on EZH2-Targeted Drugs.

Authors:  Jemma Longley; Peter W M Johnson
Journal:  Curr Oncol Rep       Date:  2021-05-03       Impact factor: 5.075

5.  Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds.

Authors:  Deborah O Dele-Oni; Karen E Christianson; Shawn B Egri; Alvaro Sebastian Vaca Jacome; Katherine C DeRuff; James Mullahoo; Vagisha Sharma; Desiree Davison; Tak Ko; Michael Bula; Joel Blanchard; Jennie Z Young; Lev Litichevskiy; Xiaodong Lu; Daniel Lam; Jacob K Asiedu; Caidin Toder; Adam Officer; Ryan Peckner; Michael J MacCoss; Li-Huei Tsai; Steven A Carr; Malvina Papanastasiou; Jacob D Jaffe
Journal:  Sci Data       Date:  2021-08-25       Impact factor: 6.444

6.  Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma.

Authors:  Kirill Batmanov; Wei Wang; Magnar Bjørås; Jan Delabie; Junbai Wang
Journal:  Sci Rep       Date:  2017-08-01       Impact factor: 4.379
  6 in total

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