| Literature DB >> 2409532 |
G Langsley, A Scherf, O Mercereau-Puijalon, M Koenen, B Kahane, D Mattei, M Guillotte, L Sibilli, I Garner, B Müller-Hill.
Abstract
A genomic expression library of P.falciparum has been differentially screened with a number of immune sera. The response of 9 clones to the various sera is presented, together with the DNA sequence encoding the epitopes. All but one clone are extremely A+T rich and unlike the other P.falciparum epitopes described, are not composed of amino acid repeats. One clone, which responds specifically with a protective serum, has been analysed in detail. The epitope is carried on a 160kd antigen which is transcribed from a single gene to give a protein expressed in all of the erythrocytic forms. DNA sequence of this clone reveals it to have more than one open reading frame, only one of which is transcribed in the blood stages. The possible significance of the other open readings frames is discussed.Entities:
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Year: 1985 PMID： 2409532 PMCID： PMC341305 DOI： 10.1093/nar/13.11.4191
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971