BACKGROUND: Evidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment results in a modest reduction in glycosylated hemoglobin (Hb) A1c. PURPOSE: The purpose of the Diabetes and Periodontal Therapy Trial (DPTT) was to determine if periodontal treatment reduces HbA1c in patients with T2DM and periodontitis. METHODS: DPTT was a phase-III, single-masked, multi-center, randomized trial with a planned enrollment of 600 participants. Participants were randomly assigned to receive periodontal treatment immediately (Treatment Group) or after 6 months (Control Group). HbA1c values and clinical periodontal measures were determined at baseline and 3 and 6 months following randomization. Medication usage and dosing were assessed at each visit. Periodontal treatment consisted of scaling and root planing for a minimum of two 90-minute sessions, plus the use of an antibacterial mouth rinse for at least 32 days afterwards. The primary outcome was change in HbA1c from baseline to 6 months and the trial was powered to detect a between-group difference of 0.6%. Secondary outcomes included changes in periodontal clinical measures, fasting plasma glucose, the Homeostasis Model Assessment (HOMA2) and the need for rescue diabetes or periodontal therapy. CONCLUSION: Dental and medical researchers collaborated to recruit, treat and monitor participants with two chronic diseases to determine if treatment of one condition affects the status of the other.
RCT Entities:
BACKGROUND: Evidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment results in a modest reduction in glycosylated hemoglobin (Hb) A1c. PURPOSE: The purpose of the Diabetes and Periodontal Therapy Trial (DPTT) was to determine if periodontal treatment reduces HbA1c in patients with T2DM and periodontitis. METHODS:DPTT was a phase-III, single-masked, multi-center, randomized trial with a planned enrollment of 600 participants. Participants were randomly assigned to receive periodontal treatment immediately (Treatment Group) or after 6 months (Control Group). HbA1c values and clinical periodontal measures were determined at baseline and 3 and 6 months following randomization. Medication usage and dosing were assessed at each visit. Periodontal treatment consisted of scaling and root planing for a minimum of two 90-minute sessions, plus the use of an antibacterial mouth rinse for at least 32 days afterwards. The primary outcome was change in HbA1c from baseline to 6 months and the trial was powered to detect a between-group difference of 0.6%. Secondary outcomes included changes in periodontal clinical measures, fasting plasma glucose, the Homeostasis Model Assessment (HOMA2) and the need for rescue diabetes or periodontal therapy. CONCLUSION: Dental and medical researchers collaborated to recruit, treat and monitor participants with two chronic diseases to determine if treatment of one condition affects the status of the other.
Authors: B L Pihlstrom; L F Wolff; M B Bakdash; E M Schaffer; J R Jensen; D M Aeppli; C L Bandt Journal: J Periodontol Date: 1987-05 Impact factor: 6.993
Authors: Wenche S Borgnakke; Iain L C Chapple; Robert J Genco; Gary Armitage; P Mark Bartold; Francesco D'Aiuto; Paul I Eke; William V Giannobile; Thomas Kocher; Kenneth S Kornman; Niklaus P Lang; Phoebus N Madianos; Shinya Murakami; Fusanori Nishimura; Steven Offenbacher; Philip M Preshaw; Amin Ur Rahman; Mariano Sanz; Jørgen Slots; Maurizio S Tonetti; Thomas E Van Dyke Journal: J Evid Based Dent Pract Date: 2014-05-21 Impact factor: 5.267
Authors: Elinor R Schoenfeld; Leslie Hyman; Leslie Long Simpson; Bryan Michalowicz; Michael Reddy; Marie Gelato; Wei Hou; Steven P Engebretson; Catherine Hytner; Pat Lenton Journal: Clin Investig (Lond) Date: 2014-12-01
Authors: Terry C Simpson; Janet E Clarkson; Helen V Worthington; Laura MacDonald; Jo C Weldon; Ian Needleman; Zipporah Iheozor-Ejiofor; Sarah H Wild; Ambrina Qureshi; Andrew Walker; Veena A Patel; Dwayne Boyers; Joshua Twigg Journal: Cochrane Database Syst Rev Date: 2022-04-14
Authors: Leonardo P Faverani; Wirley G Assunção; Paulo Sérgio P de Carvalho; Judy Chia-Chun Yuan; Cortino Sukotjo; Mathew T Mathew; Valentim A Barao Journal: PLoS One Date: 2014-03-26 Impact factor: 3.240
Authors: Terry C Simpson; Jo C Weldon; Helen V Worthington; Ian Needleman; Sarah H Wild; David R Moles; Brian Stevenson; Susan Furness; Zipporah Iheozor-Ejiofor Journal: Cochrane Database Syst Rev Date: 2015-11-06