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Literature DB >> 24068836

Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes.

Shuguang Wang¹, Wentong Lu, Oleg Tovmachenko, Uma Shanker Rai, Hongtao Yu, Paresh Chandra Ray.

Abstract

As the nanotechnology field continues to develop, assessing nanoparticle toxicity is very important for advancing nanoparticles for biomedical application. Here we report cytotoxicity of gold nanomaterial of different size and shape using MTT test, absorption spectroscopy and TEM. Spherical gold nanoparticles with different sizes are not inherently toxic to human skin cells, but gold nanorods are highly toxic due to the presence of CTAB as coating material. Due to CTAB toxicity, and aggregation of gold nanomaterials in the presence of cell media, it is a real challenge to study the cytotoxicity of gold nanomaterials individually.

Entities: CellLine Chemical Disease Gene Species

Year: 2008 PMID： 24068836 PMCID： PMC3780398 DOI： 10.1016/j.cplett.2008.08.039

Source DB: PubMed Journal: Chem Phys Lett ISSN： 0009-2614 Impact factor: 2.328

23 in total

Review 1. Nanostructures in biodiagnostics.

Authors: Nathaniel L Rosi; Chad A Mirkin
Journal: Chem Rev Date: 2005-04 Impact factor: 60.622

2. Fluorescent lifetime quenching near d = 1.5 nm gold nanoparticles: probing NSET validity.

Authors: T L Jennings; M P Singh; G F Strouse
Journal: J Am Chem Soc Date: 2006-04-26 Impact factor: 15.419

3. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.

Authors: B Devika Chithrani; Arezou A Ghazani; Warren C W Chan
Journal: Nano Lett Date: 2006-04 Impact factor: 11.189

4. Diagnostics of single base-mismatch DNA hybridization on gold nanoparticles by using the hyper-Rayleigh scattering technique.

Authors: Paresh Chandra Ray
Journal: Angew Chem Int Ed Engl Date: 2006-02-06 Impact factor: 15.336

Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes.

Review 1. Nanostructures in biodiagnostics.

2. Fluorescent lifetime quenching near d = 1.5 nm gold nanoparticles: probing NSET validity.

3. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.

4. Diagnostics of single base-mismatch DNA hybridization on gold nanoparticles by using the hyper-Rayleigh scattering technique.

5. NSET molecular beacon analysis of hammerhead RNA substrate binding and catalysis.

6. Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity.

7. Ge/Si nanowire heterostructures as high-performance field-effect transistors.

8. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins.

9. In vivo cancer targeting and imaging with semiconductor quantum dots.

10. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods.

Review 1. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective.

2. Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.

3. High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes.

4. Toxic effects of gold nanoparticles on Salmonella typhimurium bacteria.

5. Experimental considerations on the cytotoxicity of nanoparticles.

6. In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets.

7. Synthesis and Cytotoxicity of Y(2)O(3) Nanoparticles of Various Morphologies.

Review 8. Effects of nanomaterial physicochemical properties on in vivo toxicity.

9. Toxicity and environmental risks of nanomaterials: challenges and future needs.

Review 10. Toxicity of engineered nanomaterials: a physicochemical perspective.