| Literature DB >> 34295454 |
Ziyi Zhang1, Dalong Ni2,3, Fei Wang1, Xin Yin1, Shreya Goel2, Lazarus N German1, Yizhan Wang1, Jun Li1, Weibo Cai2,3, Xudong Wang1.
Abstract
Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm. These Au NSs were found very effective in generating singlet oxygen under NIR irradiation. In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.Entities:
Keywords: cancer therapy; gold nanosheet; ionic layer epitaxy; photodynamic effect; surface plasmon
Year: 2020 PMID： 34295454 PMCID： PMC8291290 DOI： 10.1007/s12274-020-2990-7
Source DB: PubMed Journal: Nano Res ISSN： 1998-0000 Impact factor: 8.897