Literature DB >> 24050192

Modulation of CEST images in vivo by T1 relaxation: a new approach in the design of responsive PARACEST agents.

S James Ratnakar1, Todd C Soesbe, Lloyd Laporca Lumata, Quyen N Do, Subha Viswanathan, Chien-Yuan Lin, A Dean Sherry, Zoltan Kovacs.   

Abstract

A novel approach for the design of responsive paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) agents has been developed where the signal is "turned on" by altering the longitudinal relaxation time (T1) of bulk water protons. To demonstrate this approach, a model Eu(DOTA-tetraamide) complex (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) containing two nitroxide free radical units was synthesized. The nitroxide groups substantially shortened the T1 of the bulk water protons which, in turn, resulted in quenching of the CEST signal. Reduction of paramagnetic nitroxide moieties to a diamagnetic species resulted in the appearance of CEST. The modulation of CEST by T1 relaxation provides a new platform for designing biologically responsive MRI agents.

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Year:  2013        PMID： 24050192      PMCID： PMC3858012          DOI： 10.1021/ja406738y

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  16 in total

1.  A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST).

Authors:  K M Ward; A H Aletras; R S Balaban
Journal:  J Magn Reson       Date:  2000-03       Impact factor: 2.229

2.  Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.

Authors:  Donald E Woessner; Shanrong Zhang; Matthew E Merritt; A Dean Sherry
Journal:  Magn Reson Med       Date:  2005-04       Impact factor: 4.668

3.  Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors.

Authors:  S James Ratnakar; Subha Viswanathan; Zoltan Kovacs; Ashish K Jindal; Kayla N Green; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2012-03-23       Impact factor: 15.419

4.  Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents.

Authors:  Fuminori Hyodo; Ken-Ichiro Matsumoto; Atsuko Matsumoto; James B Mitchell; Murali C Krishna
Journal:  Cancer Res       Date:  2006-10-15       Impact factor: 12.701

5.  Relaxivity enhancement of low molecular weight nitroxide stable free radicals: importance of structure and medium.

Authors:  P Vallet; Y Van Haverbeke; P A Bonnet; G Subra; J P Chapat; R N Muller
Journal:  Magn Reson Med       Date:  1994-07       Impact factor: 4.668

6.  Monitoring redox-sensitive paramagnetic contrast agent by EPRI, OMRI and MRI.

Authors:  Fuminori Hyodo; Ramachandran Murugesan; Ken-ichiro Matsumoto; Emi Hyodo; Sankaran Subramanian; James B Mitchell; Murali C Krishna
Journal:  J Magn Reson       Date:  2007-10-30       Impact factor: 2.229

7.  Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects.

Authors:  S James Ratnakar; Mark Woods; Angelo J M Lubag; Zoltan Kovacs; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2007-12-08       Impact factor: 15.419

Review 8.  The chemistry and biology of nitroxide compounds.

Authors:  Benjamin P Soule; Fuminori Hyodo; Ken-Ichiro Matsumoto; Nicole L Simone; John A Cook; Murali C Krishna; James B Mitchell
Journal:  Free Radic Biol Med       Date:  2007-03-12       Impact factor: 7.376

9.  Nitroxides as potential contrast enhancing agents for MRI application: influence of structure on the rate of reduction by rat hepatocytes, whole liver homogenate, subcellular fractions, and ascorbate.

Authors:  J F Keana; S Pou; G M Rosen
Journal:  Magn Reson Med       Date:  1987-12       Impact factor: 4.668

10.  Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agents.

Authors:  Tomoyasu Mani; Gyula Tircsó; Osamu Togao; Piyu Zhao; Todd C Soesbe; Masaya Takahashi; A Dean Sherry
Journal:  Contrast Media Mol Imaging       Date:  2009 Jul-Aug       Impact factor: 3.161
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  15 in total

1.  Imaging short-lived reactive oxygen species (ROS) with endogenous contrast MRI.

Authors:  Rong-Wen Tain; Alessandro M Scotti; Weiguo Li; Xiaohong Joe Zhou; Kejia Cai
Journal:  J Magn Reson Imaging       Date:  2017-05-15       Impact factor: 4.813

2.  Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.

Authors:  Levi A Ekanger; Devin R Mills; Meser M Ali; Lisa A Polin; Yimin Shen; E Mark Haacke; Matthew J Allen
Journal:  Inorg Chem       Date:  2016-05-31       Impact factor: 5.165

3.  The Role of Coordination Environment and pH in Tuning the Oxidation Rate of Europium(II).

Authors:  Levi A Ekanger; Lina A Basal; Matthew J Allen
Journal:  Chemistry       Date:  2016-12-19       Impact factor: 5.236

4.  A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.

Authors:  Xiaojing Wang; Yunkou Wu; Todd C Soesbe; Jing Yu; Piyu Zhao; Garry E Kiefer; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-11       Impact factor: 15.336

Review 5.  Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.

Authors:  Levi A Ekanger; Matthew J Allen
Journal:  Metallomics       Date:  2015-03       Impact factor: 4.526

6.  Oxidation-responsive Eu(2+/3+)-liposomal contrast agent for dual-mode magnetic resonance imaging.

Authors:  Levi A Ekanger; Meser M Ali; Matthew J Allen
Journal:  Chem Commun (Camb)       Date:  2014-12-07       Impact factor: 6.222

Review 7.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

Review 8.  Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths.

Authors:  Akhila N W Kuda-Wedagedara; Matthew J Allen
Journal:  Analyst       Date:  2014-09-21       Impact factor: 4.616

9.  Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor.

Authors:  Madushani Dharmarwardana; André F Martins; Zhuo Chen; Philip M Palacios; Chance M Nowak; Raymond P Welch; Shaobo Li; Michael A Luzuriaga; Leonidas Bleris; Brad S Pierce; A Dean Sherry; Jeremiah J Gassensmith
Journal:  Mol Pharm       Date:  2018-05-29       Impact factor: 4.939

Review 10.  Redox- and hypoxia-responsive MRI contrast agents.

Authors:  Quyen N Do; James S Ratnakar; Zoltán Kovács; A Dean Sherry
Journal:  ChemMedChem       Date:  2014-05-13       Impact factor: 3.466
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