Literature DB >> 18067296

Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects.

S James Ratnakar1, Mark Woods, Angelo J M Lubag, Zoltan Kovacs, A Dean Sherry.   

Abstract

The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F approximately CO2tBu < CN < H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

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Year:  2007        PMID： 18067296      PMCID： PMC2716115          DOI： 10.1021/ja076325y

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  16 in total

1.  A novel europium(III)-based MRI contrast agent.

Authors:  S Zhang; P Winter; K Wu; A D Sherry
Journal:  J Am Chem Soc       Date:  2001-02-21       Impact factor: 15.419

2.  Novel pH-reporter MRI contrast agents.

Authors:  Silvio Aime; Daniela Delli Castelli; Enzo Terreno
Journal:  Angew Chem Int Ed Engl       Date:  2002-11-15       Impact factor: 15.336

Review 3.  PARACEST agents: modulating MRI contrast via water proton exchange.

Authors:  Shanrong Zhang; Matthew Merritt; Donald E Woessner; Robert E Lenkinski; A Dean Sherry
Journal:  Acc Chem Res       Date:  2003-10       Impact factor: 22.384

4.  A paramagnetic MRI-CEST agent responsive to lactate concentration.

Authors:  Silvio Aime; Daniela Delli Castelli; Franco Fedeli; Enzo Terreno
Journal:  J Am Chem Soc       Date:  2002-08-14       Impact factor: 15.419

5.  Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes.

Authors:  Mark Woods; Zoltan Kovacs; Shanrong Zhang; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2003       Impact factor: 15.336

6.  Controlling the variation of axial water exchange rates in macrocyclic lanthanide(III) complexes.

Authors:  Silvio Aime; Alessandro Barge; Andrei S Batsanov; Mauro Botta; Daniela Delli Castelli; Franco Fedeli; Armando Mortillaro; David Parker; Horst Puschmann
Journal:  Chem Commun (Camb)       Date:  2002-05-21       Impact factor: 6.222

7.  Selective sensing of zinc ions with a PARACEST contrast agent.

Authors:  Robert Trokowski; Jimin Ren; Ferenc Krisztián Kálmán; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2005-10-28       Impact factor: 15.336

8.  Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.

Authors:  Donald E Woessner; Shanrong Zhang; Matthew E Merritt; A Dean Sherry
Journal:  Magn Reson Med       Date:  2005-04       Impact factor: 4.668

9.  Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexes.

Authors:  Shanrong Zhang; Kuangcong Wu; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2002-04-24       Impact factor: 15.419

10.  Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRI.

Authors:  Robert Trokowski; Shanrong Zhang; A Dean Sherry
Journal:  Bioconjug Chem       Date:  2004 Nov-Dec       Impact factor: 4.774
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  28 in total

Review 1.  Alternatives to gadolinium-based metal chelates for magnetic resonance imaging.

Authors:  Subha Viswanathan; Zoltan Kovacs; Kayla N Green; S James Ratnakar; A Dean Sherry
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

2.  Crystallographic Characterization and Non-Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on EuIII Electrochemistry.

Authors:  Marianne E Burnett; Bukola Adebesin; S James Ratnakar; Kayla N Green
Journal:  Eur J Inorg Chem       Date:  2018-03-23       Impact factor: 2.524

Review 3.  Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.

Authors:  A Dean Sherry; Mark Woods
Journal:  Annu Rev Biomed Eng       Date:  2008       Impact factor: 9.590

Review 4.  Smart MR imaging agents relevant to potential neurologic applications.

Authors:  C S Bonnet; E Tóth
Journal:  AJNR Am J Neuroradiol       Date:  2009-10-15       Impact factor: 3.825

5.  A Frequency-Selective pH-Responsive paraCEST Agent.

Authors:  S James Ratnakar; Sara Chirayil; Alexander M Funk; Shanrong Zhang; João F Queiró; Carlos F G C Geraldes; Zoltan Kovacs; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-06       Impact factor: 15.336

6.  Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors.

Authors:  S James Ratnakar; Subha Viswanathan; Zoltan Kovacs; Ashish K Jindal; Kayla N Green; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2012-03-23       Impact factor: 15.419

7.  Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.

Authors:  Levi A Ekanger; Devin R Mills; Meser M Ali; Lisa A Polin; Yimin Shen; E Mark Haacke; Matthew J Allen
Journal:  Inorg Chem       Date:  2016-05-31       Impact factor: 5.165

Review 8.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

9.  Using two chemical exchange saturation transfer magnetic resonance imaging contrast agents for molecular imaging studies.

Authors:  M Meser Ali; Guanshu Liu; Tejas Shah; Chris A Flask; Mark D Pagel
Journal:  Acc Chem Res       Date:  2009-07-21       Impact factor: 22.384

10.  Chemical Exchange Saturation Transfer is Unaffected by Modest Changes in Pressure.

Authors:  Benjamin C Webber; Christiane E Carney; Mark Woods
Journal:  Eur J Inorg Chem       Date:  2012-01-09       Impact factor: 2.524
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