Literature DB >> 25579206

Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.

Levi A Ekanger1, Matthew J Allen.   

Abstract

In magnetic resonance imaging, contrast agents are molecules that increase the contrast-to-noise ratio of non-invasively acquired images. The information gained from magnetic resonance imaging can be increased using responsive contrast agents that undergo chemical changes, and consequently changes to contrast enhancement, for example in response to specific biomarkers that are indicative of diseases. A major limitation with modern responsive contrast agents is concentration-dependence that requires the concentration of contrast agent to be known: an extremely challenging task in vivo. Here, we review advances in several strategies aimed at overcoming the concentration-dependent nature of responsive contrast agents.

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Year:  2015        PMID： 25579206      PMCID： PMC4357574          DOI： 10.1039/c4mt00289j

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  84 in total

1.  Relaxivity optimization of a PEGylated iron-oxide-based negative magnetic resonance contrast agent for T₂-weighted spin-echo imaging.

Authors:  Elmar Pöselt; Hauke Kloust; Ulrich Tromsdorf; Marcus Janschel; Christoph Hahn; Christoph Maßlo; Horst Weller
Journal:  ACS Nano       Date:  2012-01-31       Impact factor: 15.881

Review 2.  Lanthanide probes for bioresponsive imaging.

Authors:  Marie C Heffern; Lauren M Matosziuk; Thomas J Meade
Journal:  Chem Rev       Date:  2013-12-13       Impact factor: 60.622

3.  Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent.

Authors:  Nevin McVicar; Alex X Li; Mojmír Suchý; Robert H E Hudson; Ravi S Menon; Robert Bartha
Journal:  Magn Reson Med       Date:  2012-11-19       Impact factor: 4.668

Review 4.  Strategies for the development of gadolinium-based 'q'-activatable MRI contrast agents.

Authors:  Chuqiao Tu; Angelique Y Louie
Journal:  NMR Biomed       Date:  2012-09-27       Impact factor: 4.044

5.  Imaging in vivo extracellular pH with a single paramagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent.

Authors:  Guanshu Liu; Yuguo Li; Vipul R Sheth; Mark D Pagel
Journal:  Mol Imaging       Date:  2012-02       Impact factor: 4.488

6.  Highly soluble tris-hydroxypyridonate Gd(III) complexes with increased hydration number, fast water exchange, slow electronic relaxation, and high relaxivity.

Authors:  Eric J Werner; Stefano Avedano; Mauro Botta; Benjamin P Hay; Evan G Moore; Silvio Aime; Kenneth N Raymond
Journal:  J Am Chem Soc       Date:  2007-01-30       Impact factor: 15.419

7.  Synthesis and characterization of a redox- and light-sensitive MRI contrast agent.

Authors:  Chuqiao Tu; Elizabeth A Osborne; Angelique Y Louie
Journal:  Tetrahedron       Date:  2009-02       Impact factor: 2.457

8.  Comprehensive evaluation of the physicochemical properties of Ln(III) complexes of aminoethyl-DO3A as pH-responsive T(1) -MRI contrast agents.

Authors:  Zsolt Baranyai; Gabriele A Rolla; Roberto Negri; Attila Forgács; Giovanni B Giovenzana; Lorenzo Tei
Journal:  Chemistry       Date:  2014-02-07       Impact factor: 5.236

Review 9.  Redox- and hypoxia-responsive MRI contrast agents.

Authors:  Quyen N Do; James S Ratnakar; Zoltán Kovács; A Dean Sherry
Journal:  ChemMedChem       Date:  2014-05-13       Impact factor: 3.466

10.  Poly-beta-cyclodextrin based platform for pH mapping via a ratiometric 19F/1H MRI method.

Authors:  Eliana Gianolio; Roberta Napolitano; Franco Fedeli; Francesca Arena; Silvio Aime
Journal:  Chem Commun (Camb)       Date:  2009-09-21       Impact factor: 6.222
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  17 in total

1.  Measurement of the Dissociation of EuII-Containing Cryptates Using Murexide.

Authors:  Chamika U Lenora; Richard J Staples; Matthew J Allen
Journal:  Inorg Chem       Date:  2019-02-19       Impact factor: 5.165

2.  Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.

Authors:  Levi A Ekanger; Devin R Mills; Meser M Ali; Lisa A Polin; Yimin Shen; E Mark Haacke; Matthew J Allen
Journal:  Inorg Chem       Date:  2016-05-31       Impact factor: 5.165

3.  Aqueous Lanthanide Chemistry in Asymmetric Catalysis and Magnetic Resonance Imaging.

Authors:  Matthew J Allen
Journal:  Synlett       Date:  2016-06       Impact factor: 2.454

4.  The Role of Coordination Environment and pH in Tuning the Oxidation Rate of Europium(II).

Authors:  Levi A Ekanger; Lina A Basal; Matthew J Allen
Journal:  Chemistry       Date:  2016-12-19       Impact factor: 5.236

5.  In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

Authors:  Bruce A Berkowitz; Jacob Lenning; Nikita Khetarpal; Catherine Tran; Johnny Y Wu; Ali M Berri; Kristin Dernay; E Mark Haacke; Fatema Shafie-Khorassani; Robert H Podolsky; John C Gant; Shaniya Maimaiti; Olivier Thibault; Geoffrey G Murphy; Brian M Bennett; Robin Roberts
Journal:  FASEB J       Date:  2017-06-07       Impact factor: 5.191

6.  A Eu(II)-Containing Cryptate as a Redox Sensor in Magnetic Resonance Imaging of Living Tissue.

Authors:  Levi A Ekanger; Lisa A Polin; Yimin Shen; E Mark Haacke; Philip D Martin; Matthew J Allen
Journal:  Angew Chem Int Ed Engl       Date:  2015-10-02       Impact factor: 15.336

7.  Myelin-targeted, texaphyrin-based multimodal imaging agent for magnetic resonance and optical imaging.

Authors:  Sashiprabha M Vithanarachchi; Casey D Foley; Sarah Trimpin; James R Ewing; Meser M Ali; Matthew J Allen
Journal:  Contrast Media Mol Imaging       Date:  2016-09-06       Impact factor: 3.161

8.  Evaluation of Eu(II) -based positive contrast enhancement after intravenous, intraperitoneal, and subcutaneous injections.

Authors:  Levi A Ekanger; Lisa A Polin; Yimin Shen; E Mark Haacke; Matthew J Allen
Journal:  Contrast Media Mol Imaging       Date:  2016-03-30       Impact factor: 3.161

9.  Measuring In Vivo Free Radical Production by the Outer Retina.

Authors:  Bruce A Berkowitz; Bryce X Bredell; Christopher Davis; Marijana Samardzija; Christian Grimm; Robin Roberts
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-12       Impact factor: 4.799

10.  Magnetic resonance thermometry using a GdIII-based contrast agent.

Authors:  S A Amali S Subasinghe; Jonathan Romero; Cassandra L Ward; Matthew D Bailey; Donna R Zehner; Prakrut J Mehta; Fabio Carniato; Mauro Botta; Jason T Yustein; Robia G Pautler; Matthew J Allen
Journal:  Chem Commun (Camb)       Date:  2021-01-21       Impact factor: 6.222
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