Literature DB >> 26096197

A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.

Xiaojing Wang1, Yunkou Wu2, Todd C Soesbe2, Jing Yu1, Piyu Zhao1, Garry E Kiefer1,3, A Dean Sherry4,5.   

Abstract

A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  imaging agents; lanthanides; magnetic resonance imaging; magnetization transfer; paraCEST

Mesh：

Substances：

Year:  2015        PMID： 26096197      PMCID： PMC4657548          DOI： 10.1002/anie.201502497

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  22 in total

Review 1.  PARACEST agents: modulating MRI contrast via water proton exchange.

Authors:  Shanrong Zhang; Matthew Merritt; Donald E Woessner; Robert E Lenkinski; A Dean Sherry
Journal:  Acc Chem Res       Date:  2003-10       Impact factor: 22.384

2.  Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T.

Authors:  Dario Livio Longo; Walter Dastrù; Giuseppe Digilio; Jochen Keupp; Sander Langereis; Stefania Lanzardo; Simone Prestigio; Oliver Steinbach; Enzo Terreno; Fulvio Uggeri; Silvio Aime
Journal:  Magn Reson Med       Date:  2011-01       Impact factor: 4.668

3.  Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.

Authors:  Donald E Woessner; Shanrong Zhang; Matthew E Merritt; A Dean Sherry
Journal:  Magn Reson Med       Date:  2005-04       Impact factor: 4.668

4.  Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action.

Authors:  Peter Caravan
Journal:  Acc Chem Res       Date:  2009-07-21       Impact factor: 22.384

Review 5.  Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.

Authors:  A Dean Sherry; Mark Woods
Journal:  Annu Rev Biomed Eng       Date:  2008       Impact factor: 9.590

Review 6.  Classification and basic properties of contrast agents for magnetic resonance imaging.

Authors:  Carlos F G C Geraldes; Sophie Laurent
Journal:  Contrast Media Mol Imaging       Date:  2009 Jan-Feb       Impact factor: 3.161

7.  Measuring in vivo tumor pHe with CEST-FISP MRI.

Authors:  Vipul R Sheth; Yuguo Li; Liu Qi Chen; Christine M Howison; Chris A Flask; Mark D Pagel
Journal:  Magn Reson Med       Date:  2011-10-25       Impact factor: 4.668

8.  Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI.

Authors:  Liu Qi Chen; Christine M Howison; Justin J Jeffery; Ian F Robey; Phillip H Kuo; Mark D Pagel
Journal:  Magn Reson Med       Date:  2013-11-26       Impact factor: 4.668

9.  In vivo maps of extracellular pH in murine melanoma by CEST-MRI.

Authors:  D Delli Castelli; Giuseppe Ferrauto; Juan Carlos Cutrin; Enzo Terreno; Silvio Aime
Journal:  Magn Reson Med       Date:  2013-03-25       Impact factor: 4.668

Review 10.  The importance of water exchange rates in the design of responsive agents for MRI.

Authors:  A Dean Sherry; Yunkou Wu
Journal:  Curr Opin Chem Biol       Date:  2013-01-17       Impact factor: 8.822
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  7 in total

1.  A Frequency-Selective pH-Responsive paraCEST Agent.

Authors:  S James Ratnakar; Sara Chirayil; Alexander M Funk; Shanrong Zhang; João F Queiró; Carlos F G C Geraldes; Zoltan Kovacs; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-06       Impact factor: 15.336

2.  A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes.

Authors:  Matthew W Rotz; Robert J Holbrook; Keith W MacRenaris; Thomas J Meade
Journal:  Bioconjug Chem       Date:  2018-10-10       Impact factor: 4.774

3.  Gear Up for a pH Shift: A Responsive Iron(II) 2-Amino-6-picolyl-Appended Macrocyclic paraCEST Agent That Protonates at a Pendent Group.

Authors:  Pavel B Tsitovich; Jordan M Cox; Joseph A Spernyak; Janet R Morrow
Journal:  Inorg Chem       Date:  2016-11-04       Impact factor: 5.165

4.  Lanthanide-Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents.

Authors:  Lei Zhang; André F Martins; Piyu Zhao; Yunkou Wu; Gyula Tircsó; A Dean Sherry
Journal:  Angew Chem Int Ed Engl       Date:  2017-12-04       Impact factor: 15.336

Review 5.  Functional nanoparticles for magnetic resonance imaging.

Authors:  Xinpei Mao; Jiadi Xu; Honggang Cui
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2016-04-04

Review 6.  Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection.

Authors:  Sanhita Sinharay; Mark D Pagel
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2016-03-30       Impact factor: 10.745

7.  Amplifying undetectable NMR signals to study host-guest interactions and exchange.

Authors:  Liat Avram; Mark A Iron; Amnon Bar-Shir
Journal:  Chem Sci       Date:  2016-10-05       Impact factor: 9.825
  7 in total

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