| Literature DB >> 24013645 |
Sari Räisänen1, Rufus Cartwright, Mika Gissler, Michael R Kramer, Seppo Heinonen.
Abstract
BACKGROUND: Obstetric anal sphincter injury (OASIS) has been identified as a major preventable risk factor for anal incontinence.Entities:
Mesh:
Year: 2013 PMID: 24013645 PMCID: PMC3754956 DOI: 10.1371/journal.pone.0073515
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Delivery characteristics and interventions were compared between women delivered vaginally with and without OASIS within the groups of nulliparous women including women admitted for first vaginal delivery after a prior cesarean section for their first birth (n = 417,671) and multiparous women (n = 563,062) between 1991 and 2010 in Finland.
| Delivery intervention/characteristic | Nulliparae and women with first vaginal delivery after a prior Cesarean section for their first birth | Multiparae | ||||
| % or Mean (SD) | With OASIS (1.2%, n = 4,939), % or mean (SD) | Without OASIS, % or mean (SD) | p value* | With OASIS (0.3%, n = 1,465), % or mean (SD) | Without OASIS, % or mean (SD) | p value* |
| Mean maternal age (SD) (year) | 28.3(4.8) | 27.0 (5.0) | ≤0.001 | 30.7 (4.8) | 30.6 (5.0) | 0.51 |
| Mean gestational age (SD) (wk) | 40.3 (1.3) | 39.9 (1.7) | ≤0.001 | 40.2 (1.2) | 39.9 (1.6) | ≤0.001 |
| Mean birthweight (SD) (g) | 3683.7 (453.4) | 3459.8 (504.3) | ≤0.001 | 3866.8 (486.4) | 3642.0 (516.2) | ≤0.001 |
| Mode of delivery | ≤0.001 | ≤0.001 | ||||
| Vaginal delivery | 0.9 | 99.1 | 0.2 | 99.8 | ||
| Breech | 0.9 | 99.1 | 0.3 | 99.7 | ||
| Forceps | 3.4 | 96.6 | 0.9 | 99.1 | ||
| Vacuum assistance | 2.8 | 97.2 | 1.0 | 99.0 | ||
| Induction | 1.1 | 98.9 | ≤0.001 | 0.3 | 99.7 | 0.15 |
| Augmentation with oxytocin | 1.2 | 98.8 | 0.001 | 0.3 | 99.7 | 0.003 |
| Episiotomy | 1.2 | 98.8 | 0.82 | 0.3 | 99.7 | 0.001 |
| Epidural analgesia | 1.3 | 98.7 | ≤0.001 | 0.3 | 99.7 | ≤0.001 |
| Socioeconomic group | ≤0.001 | 0.001 | ||||
| Upper white-collar worker | 1.4 | 98.6 | 0.3 | 99.7 | ||
| Lower white-collar worker | 1.1 | 98.9 | 0.3 | 99.7 | ||
| Blue-collar worker | 0.9 | 99.1 | 0.2 | 99.8 | ||
| Other | 1.2 | 98.8 | 0.2 | 99.8 | ||
| Missing | 1.5 | 98.5 | 0.3 | 99.7 | ||
| Prior cesarean section | 1.9 | 98.1 | ≤0.001 | 0.3 | 99.7 | 0.19 |
| Smoking status | ≤0.001 | ≤0.001 | ||||
| Non-smoking | 1.3 | 98.7 | 0.3 | 99.7 | ||
| Quitted smoking | 1.1 | 98.9 | 0.2 | 99.8 | ||
| Smoking | 0.7 | 99.3 | 0.2 | 99.8 | ||
| Time periods | ≤0.001 | ≤0.001 | ||||
| 1991−1995 | 0.3 | 99.7 | 0.1 | 99.9 | ||
| 1997−2000 | 0.6 | 99.4 | 0.1 | 99.9 | ||
| 2001−2005 | 1.6 | 98.1 | 0.6 | 99.4 | ||
| 2006−2010 | 2.3 | 97.7 | 0.3 | 99.6 | ||
OASIS = obstetric anal sphincter injuries, SD = standard deviation, (*Chi Square, Mann-Whitney U or Student’s t tests).
Characteristics and background information were compared in nulliparous women including women with first vaginal delivery after a prior cesarean section between SES groups in 1991−2010 in Finland.
| Characteristic | Upper white-collar worker | Lower white-collar worker | Blue-collar worker | Others | Missing | p value* |
| OASIS % | 1.4 | 1.1 | 0.9 | 1.2 | 1.5 | ≤0.001 |
| Mean maternal age (SD) (year) | 30.1 (4.0) | 27.8 (4.5) | 25.8 (4.7) | 26.0 (5.3) | 26.4 (5.4) | ≤0.001 |
| Mean gestational age (SD) (wk) | 39.9 (1.7) | 39.9 (1.7) | 39.9 (1.8) | 39.9 (1.7) | 39.9 (1.9) | ≤0.001 |
| Mean birthweight (SD) (g) | 3480.3 (491.8) | 3470.6 (500.2) | 3451.0 (515.5) | 3465.1 (498.7) | 3441.0 (516.7) | ≤0.001 |
| Mode of delivery % | ≤0.001 | |||||
| Vaginal spontaneous | 61.4 | 63.0 | 65.4 | 68.0 | 65.2 | |
| Breech | 0.4 | 0.4 | 0.4 | 0.5 | 0.6 | |
| Forceps | 0.2 | 0.3 | 0.3 | 0.2 | 0.2 | |
| Vacuum | 12.6 | 11.7 | 11.0 | 11.0 | 12.2 | |
| Cesarean section b | 25.4 | 24.6 | 22.9 | 20.3 | 21.8 | |
| Epidural analgesia % | 55.1 | 53.3 | 51.9 | 58.0 | 58.3 | ≤0.001 |
| Smoking status % | ≤0.001 | |||||
| Non-smoking | 95.0 | 85.4 | 71.5 | 83.7 | 79.6 | |
| Quitted smoking | 1.4 | 3.4 | 5.1 | 3.7 | 4.7 | |
| Smoking | 3.6 | 11.3 | 23.4 | 12.6 | 15.7 |
The ‘other’ group included entrepreneurs, students, retired, unemployed, housewives and unclassifiable cases,b Additional information, *Chi Square or Analysis of Variance (ANOVA) tests.
Adjusted odds ratio (OR) of OASIS in nulliparous women including women admitted for first vaginal delivery after a prior cesarean section for their first birth (n = 408,272) and multiparous women (n = 547,257) women with singleton births between 1991 and 2010 in Finland (Logistic regression).
| Delivery intervention/characteristic | Nulliparae and women with first vaginal delivery adjusted OR (95% CI) | Multiparous women adjusted OR (95% CI) |
| Maternal age (year) | ||
| ≤19 | 1 | |
| 20−29 (≥29 ref multip) | 1.56 (1.31−1.85) | 1 |
| 30−39 | 1.81 (1.52−2.16) | 0.98 (0.88−1.10) |
| ≥40 | 1.34 (0.99−1.83) | 0.93 (0.72−1.22) |
| Gestational age (wk) | ||
| <37 | 1 | 1 |
| 37−39+6 | 1.43 (1.13−1.81) | 1.15 (0.71−1.84) |
| 40−41+6 | 1.49 (1.18−1.89) | 1.28 (0.79−2.06) |
| >42 | 1.65 (1.27−2.15) | 1.35 (0.76−2.38) |
| Birthweight (g) | ||
| <3000 | 1 | 1 |
| 3000−3499 | 1.65 (1.45−1.88) | 1.50 (1.09−2.07) |
| 3500−3999 | 2.44 (2.14−2.78) | 2.28 (1.67−3.12) |
| ≥4000 | 3.94 (3.43−4.53) | 3.64 (2.65−5.01) |
| Mode of delivery | ||
| Vaginal delivery | 1 | 1 |
| Breech | 1.04 (0.68−1.61) | 0.77 (0.32−1.86) |
| Forceps | 4.44 (3.18−6.21) | 4.97 (1.21−20.34) |
| Vacuum | 2.54 (2.38−2.71) | 2.79 (2.26−3.44) |
| Prior cesarean section | 1.38 (1.26−1.50) | 1.01 (0.81−1.27) |
| Induction | 0.98 (0.91−1.06) | 0.96 (0.83−1.10) |
| Augmentation with oxytocin | 1.02 (0.95−1.08) | 0.95 (0.85−1.07) |
| Episiotomy | 0.98 (0.92−1.05) | 1.70 (1.49−1.94) |
| Epidural analgesia | 0.87 (0.81−0.92) | 0.88 (0.77−1.01) |
| Socioeconomic group | ||
| Upper white-collar worker | 1.18 (1.04−1.34) | 0.95 (0.75−1.19) |
| Lower white-collar worker | 1.12 (1.02−1.24) | 1.07 (0.91−1.25) |
| Blue-collar worker | 1 | 1 |
| Other | 1.13 (1.02−1.25) | 0.88 (0.74−1.04) |
| Missing | 1.17 (1.05−1.30) | 1.06 (0.88−1.29) |
| Smoking status | ||
| Non-smoking | 1 | 1 |
| Quitted smoking | 0.74 (0.64−0.87) | 0.47 (0.29−0.77) |
| Smoking | 0.80 (0.72−0.89) | 0.85 (0.70−1.03) |
| Time periods | ||
| 1991−1995 | 1 | 1 |
| 1996−2000 | 1.80 (1.57−2.06) | 1.85 (1.41−2.43) |
| 2001−2005 | 5.13 (4.55−5.78) | 12.51 (9.98−15.67) |
| 2006−2010 | 7.14 (6.35−8.03) | 7.67 (6.06−9.71) |
The ‘other’ group included entrepreneurs, students, retired, unemployed, housewives and unclassifiable cases.
Odds ratios (ORs) of OASIS in nulliparous women including women admitted for first vaginal delivery after a prior cesarean section after adjustments for age and risk factors for OASIS.
| Model 1, crude | Model 2, adjusted by SES and age | Model 3, adjusted by Model 2 and smoking | Model 4, adjusted by Model 2 and birthweight | Model 5, adjusted by Model 2 and mode of delivery | Model 6, adjusted by Model 2 and smoking, birthweight and mode of delivery | ||||||
| OR (95% CI) | OR (95% CI) | Diff. with 1 (%) | OR (95% CI) | Diff. with 2 (%) | OR (95% CI) | Diff. with 2 (%) | OR (95% CI) | Diff. with 2 (%) | OR (95% CI) | Diff. with 2 (%) | |
| SES | |||||||||||
| Upper white-collar | 1.57 (1.39−1.78) | 1.38 (1.23−1.44) | 33.3 | 1.21 (1.07−1.38) | 44.7 | 1.24 (1.10−1.41) | 36.8 | 1.30 (1.15−1.47) | 21.1 | 1.23 (1.08−1.39) | 39.5 |
| Lower white-collar | 1.23 (1.12−1.35) | 1.12 (1.02−1.23) | 47.8 | 1.08 (0.98−1.18) | 33.3 | 1.10 (1.00−1.21) | 16.7 | 1.12 (1.02−1.24) | - | 1.08 (0.98−1.19) | 33.3 |
| Blue-collar | 1 | 1 | - | 1 | - | 1 | - | 1 | - | 1 | - |
| Other a | 1.35 (1.22−1.48) | 1.32 (1.20−1.46) | 8.6 | 1.28 (1.16−1.41) | 12.5 | 1.31 (1.19−1.44) | 3.1 | 1.34 (1.22−1.48) | - | 1.30 (1.18−1.44) | 6.3 |
| Missing | 1.64 (1.48−1.82) | 1.58 (1.42−1.75) | 9.4 | 1.55 (1.39−1.72) | 5.2 | 1.59 (1.43−1.76) | - | 1.57 (1.41−1.74) | 1.7 | 1.56 (1.40−1.73) | 3.4 |
SES = socioeconomic status, a The ‘other’ group included entrepreneurs, students, retired, unemployed, housewives and unclassifiable cases.
The contribution of risk factors for OASIS to socioeconomic disparities in OASIS were measured by the percentage reduction in the odds ratio of each SES group compared to Model 2 by using formula (OR Model 2 – OR Model 3/4/5/6)/(OR Model 2 – 1).