Literature DB >> 23989661

Tissue-dependent regulation of RNAP II dynamics: the missing link between transcription and trinucleotide repeat instability in diseases?

Agathi-Vasiliki Goula1, Richard Festenstein, Karine Merienne.   

Abstract

More than 15 human genetic diseases, including Huntington's disease, result from the expansion of a trinucleotide repeat. The expansions are unstable in specific somatic tissues, which can lead to disease acceleration. Here we discuss the role of transcription elongation in tissue-selective trinucleotide repeat instability.

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Year:  2013        PMID： 23989661      PMCID： PMC3977917          DOI： 10.4161/trns.25971

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  30 in total

1.  Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II.

Authors:  Subhrangsu S Mandal; Chun Chu; Tadashi Wada; Hiroshi Handa; Aaron J Shatkin; Danny Reinberg
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-10       Impact factor: 11.205

2.  Transcription promotes contraction of CAG repeat tracts in human cells.

Authors:  Yunfu Lin; Vincent Dion; John H Wilson
Journal:  Nat Struct Mol Biol       Date:  2006-01-01       Impact factor: 15.369

Review 3.  Breaking barriers to transcription elongation.

Authors:  Abbie Saunders; Leighton J Core; John T Lis
Journal:  Nat Rev Mol Cell Biol       Date:  2006-08       Impact factor: 94.444

4.  Effects of molecular memory and bursting on fluctuations in gene expression.

Authors:  Juan M Pedraza; Johan Paulsson
Journal:  Science       Date:  2008-01-18       Impact factor: 47.728

5.  Are gene loops the cause of transcriptional noise?

Authors:  Daniel Hebenstreit
Journal:  Trends Genet       Date:  2013-05-09       Impact factor: 11.639

Review 6.  Repeat instability as the basis for human diseases and as a potential target for therapy.

Authors:  Arturo López Castel; John D Cleary; Christopher E Pearson
Journal:  Nat Rev Mol Cell Biol       Date:  2010-03       Impact factor: 94.444

7.  Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

Authors:  Agathi-Vassiliki Goula; Brian R Berquist; David M Wilson; Vanessa C Wheeler; Yvon Trottier; Karine Merienne
Journal:  PLoS Genet       Date:  2009-12-04       Impact factor: 5.917

8.  Single-RNA counting reveals alternative modes of gene expression in yeast.

Authors:  Daniel Zenklusen; Daniel R Larson; Robert H Singer
Journal:  Nat Struct Mol Biol       Date:  2008-11-16       Impact factor: 15.369

9.  Somatic instability of the CTG repeat in mice transgenic for the myotonic dystrophy region is age dependent but not correlated to the relative intertissue transcription levels and proliferative capacities.

Authors:  A S Lia; H Seznec; H Hofmann-Radvanyi; F Radvanyi; C Duros; C Saquet; M Blanche; C Junien; G Gourdon
Journal:  Hum Mol Genet       Date:  1998-08       Impact factor: 6.150

10.  Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats.

Authors:  Kaalak Reddy; Mandy Tam; Richard P Bowater; Miriam Barber; Matthew Tomlinson; Kerrie Nichol Edamura; Yuh-Hwa Wang; Christopher E Pearson
Journal:  Nucleic Acids Res       Date:  2010-11-04       Impact factor: 16.971
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  2 in total

Review 1.  The Repeat Expansion Diseases: The dark side of DNA repair.

Authors:  Xiao-Nan Zhao; Karen Usdin
Journal:  DNA Repair (Amst)       Date:  2015-04-30

Review 2.  Repeat instability during DNA repair: Insights from model systems.

Authors:  Karen Usdin; Nealia C M House; Catherine H Freudenreich
Journal:  Crit Rev Biochem Mol Biol       Date:  2015-01-22       Impact factor: 8.250
  2 in total

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