Literature DB >> 16388310

Transcription promotes contraction of CAG repeat tracts in human cells.

Yunfu Lin1, Vincent Dion, John H Wilson.   

Abstract

Induced transcription through CAG repeats in human cells increases repeat contraction approximately 15-fold in both confluent and proliferating cells. Repeats are stabilized against contraction by siRNA knockdown of MSH2, MSH3 or XPA, but not by knockdown of MSH6, XPC or FEN1. These results define a pathway for CAG.CTG repeat contraction that is initiated by transcription, depends on elements of mismatch and nucleotide-excision repair and does not require DNA replication.

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Year:  2006        PMID： 16388310     DOI： 10.1038/nsmb1042

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  97 in total

1.  Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis.

Authors:  Yunfu Lin; Mei Leng; Ma Wan; John H Wilson
Journal:  Mol Cell Biol       Date:  2010-07-20       Impact factor: 4.272

2.  Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.

Authors:  Masayuki Nakamori; Christopher E Pearson; Charles A Thornton
Journal:  Hum Mol Genet       Date:  2010-11-18       Impact factor: 6.150

3.  New insights into repeat instability: role of RNA•DNA hybrids.

Authors:  Elizabeth I McIvor; Urszula Polak; Marek Napierala
Journal:  RNA Biol       Date:  2010-09-01       Impact factor: 4.652

4.  Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats.

Authors:  Aarthy C Vallur; Nancy Maizels
Journal:  J Biol Chem       Date:  2010-07-19       Impact factor: 5.157

5.  Epigenetic therapy for Friedreich ataxia.

Authors:  Elisabetta Soragni; Wenyan Miao; Marco Iudicello; David Jacoby; Stefania De Mercanti; Marinella Clerico; Filomena Longo; Antonio Piga; Sherman Ku; Erica Campau; Jintang Du; Pablo Penalver; Myriam Rai; Joseph C Madara; Kristopher Nazor; Melinda O'Connor; Anton Maximov; Jeanne F Loring; Massimo Pandolfo; Luca Durelli; Joel M Gottesfeld; James R Rusche
Journal:  Ann Neurol       Date:  2014-09-16       Impact factor: 10.422

Review 6.  DNA base excision repair: a mechanism of trinucleotide repeat expansion.

Authors:  Yuan Liu; Samuel H Wilson
Journal:  Trends Biochem Sci       Date:  2012-01-27       Impact factor: 13.807

7.  The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model.

Authors:  Vahid Ezzatizadeh; Ricardo Mouro Pinto; Chiranjeevi Sandi; Madhavi Sandi; Sahar Al-Mahdawi; Hein Te Riele; Mark A Pook
Journal:  Neurobiol Dis       Date:  2012-01-20       Impact factor: 5.996

8.  Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.

Authors:  Yunfu Lin; John H Wilson
Journal:  DNA Repair (Amst)       Date:  2009-06-03

9.  Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae.

Authors:  Rangapriya Sundararajan; Lionel Gellon; Rachel M Zunder; Catherine H Freudenreich
Journal:  Genetics       Date:  2009-11-09       Impact factor: 4.562

10.  R loops stimulate genetic instability of CTG.CAG repeats.

Authors:  Yunfu Lin; Sharon Y R Dent; John H Wilson; Robert D Wells; Marek Napierala
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-22       Impact factor: 11.205
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