Literature DB >> 23979512

Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives.

Sandeep Kumar1, Nikhil Kumar, Partha Roy, Sham M Sondhi.   

Abstract

A number of isoindole (3x, 3y, 6xa-6ye), pyrrolopyrazine (3z, 6za-6ze), benzimidazoisoindole (4x, 4y, 7xa-7ye), and benzimidazopyrrolopyrazine (4z, 7za-7ze) derivatives has been synthesized in excellent yields. All these compounds were fully characterized and evaluated against five human cancer cell lines for their anti-inflammatory and antiproliferative activity. Compounds 6yc and 7zd exhibited good anti-inflammatory activity whereas compounds 6zc, 7zd (lung NCl H-522), 6ye, 7xd, 7yd, 7zc, 7zd (colon HCT-15), 6xc, 7zc (ovary PA-1), 6xc, 6yb, 6zc (liver HepG-2) exhibited good antiproliferative activity.

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Year:  2013        PMID： 23979512     DOI： 10.1007/s11030-013-9472-8

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  25 in total

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2.  Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives.

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Journal:  ACS Med Chem Lett       Date:  2012-11-21       Impact factor: 4.345

3.  Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.

Authors:  Ian R Hardcastle; Junfeng Liu; Eric Valeur; Anna Watson; Shafiq U Ahmed; Timothy J Blackburn; Karim Bennaceur; William Clegg; Catherine Drummond; Jane A Endicott; Bernard T Golding; Roger J Griffin; Jan Gruber; Karen Haggerty; Ross W Harrington; Claire Hutton; Stuart Kemp; Xiaohong Lu; James M McDonnell; David R Newell; Martin E M Noble; Sara L Payne; Charlotte H Revill; Christiane Riedinger; Qing Xu; John Lunec
Journal:  J Med Chem       Date:  2011-02-11       Impact factor: 7.446

4.  Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.

Authors:  Alaa A-M Abdel-Aziz; Kamal E H ElTahir; Yousif A Asiri
Journal:  Eur J Med Chem       Date:  2011-02-15       Impact factor: 6.514

5.  Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity.

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Journal:  Eur J Med Chem       Date:  2006-05-03       Impact factor: 6.514

6.  Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H-benzimidazoles.

Authors:  Ramanatham Vinodkumar; Sanjay Dashrath Vaidya; Bobba Venkata Siva Kumar; Umesh Nanasaheb Bhise; Shekhar Bhaskar Bhirud; Uday Chandrakant Mashelkar
Journal:  Eur J Med Chem       Date:  2007-07-10       Impact factor: 6.514

7.  Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations.

Authors:  Khalid Z Matalka; Fatema Alfarhoud; Nidal A Qinna; Eyad M Mallah; Wael A Abu-Dayyih; Zuhair A Muhi-eldeen
Journal:  Int Immunopharmacol       Date:  2012-08-09       Impact factor: 4.932

8.  Synthesis and docking studies of novel antitumor benzimidazoles.

Authors:  Mohamed A Omar; Yasser M Shaker; Shadia A Galal; Mamdouh M Ali; Sean M Kerwin; Jing Li; Harukuni Tokuda; Raghda A Ramadan; Hoda I El Diwani
Journal:  Bioorg Med Chem       Date:  2012-10-16       Impact factor: 3.641

9.  Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.

Authors:  Shoukou Lee; Chihiro Shinji; Kiyoshi Ogura; Motomu Shimizu; Satoko Maeda; Mayumi Sato; Minoru Yoshida; Yuichi Hashimoto; Hiroyuki Miyachi
Journal:  Bioorg Med Chem Lett       Date:  2007-06-13       Impact factor: 2.823

10.  Design, synthesis, and structure-activity relationship studies of new phenolic DNA gyrase inhibitors.

Authors:  Thomas Lübbers; Peter Angehrn; Hans Gmünder; Silvia Herzig
Journal:  Bioorg Med Chem Lett       Date:  2006-12-22       Impact factor: 2.823
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  2 in total

1.  Facile microwave-assisted synthesis of benzimidazole scaffolds via Ugi-type three-component condensation (3CC) reactions.

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Journal:  Mol Divers       Date:  2015-11-18       Impact factor: 2.943

2.  Solvent-free synthesis and anticancer activity evaluation of benzimidazole and perimidine derivatives.

Authors:  Anuj Kumar; Somesh Banerjee; Partha Roy; S M Sondhi; Anuj Sharma
Journal:  Mol Divers       Date:  2017-11-15       Impact factor: 2.943
  2 in total

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