Literature DB >> 17632001

Design, synthesis, and structure-activity relationship studies of new phenolic DNA gyrase inhibitors.

Thomas Lübbers1, Peter Angehrn, Hans Gmünder, Silvia Herzig.   

Abstract

Starting from a biased needle screening hit 3a, we report herein the design and synthesis of a series of novel 2,3-dihydroisoindol-1-ones structurally related to cyclothialidine 2 with DNA gyrase inhibitory activity. In this series, some compounds exhibited promising antibacterial activity against gram-positive bacterial strains.

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Year:  2006        PMID： 17632001     DOI： 10.1016/j.bmcl.2006.12.065

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Enantioselective rhodium-catalyzed isomerization of 4-iminocrotonates: asymmetric synthesis of a unique chiral synthon.

Authors:  Wen-Zhen Zhang; John C K Chu; Kevin M Oberg; Tomislav Rovis
Journal:  J Am Chem Soc       Date:  2015-01-12       Impact factor: 15.419

2.  Synthesis of d-(+)-camphor-based N-acylhydrazones and their antiviral activity.

Authors:  Kseniya S Kovaleva; Fedor I Zubkov; Nikolay I Bormotov; Roman A Novikov; Pavel V Dorovatovskii; Victor N Khrustalev; Yuriy V Gatilov; Vladimir V Zarubaev; Olga I Yarovaya; Larisa N Shishkina; Nariman F Salakhutdinov
Journal:  Medchemcomm       Date:  2018-10-26       Impact factor: 3.597

3.  Gene network analysis of Aeromonas hydrophila for novel drug target discovery.

Authors:  Vijai Singh; Dharmendra Kumar Chaudhary; Indra Mani
Journal:  Syst Synth Biol       Date:  2012-05-22

4.  Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives.

Authors:  Sandeep Kumar; Nikhil Kumar; Partha Roy; Sham M Sondhi
Journal:  Mol Divers       Date:  2013-08-27       Impact factor: 2.943

Review 5.  Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.

Authors:  Michael A Reiche; Digby F Warner; Valerie Mizrahi
Journal:  Front Mol Biosci       Date:  2017-11-14

6.  Schiff bases of indoline-2,3-dione: potential novel inhibitors of Mycobacterium tuberculosis (Mtb) DNA gyrase.

Authors:  Tarek Aboul-Fadl; Hatem A Abdel-Aziz; Mohammed K Abdel-Hamid; Tilal Elsaman; Jane Thanassi; Michael J Pucci
Journal:  Molecules       Date:  2011-09-13       Impact factor: 4.411

7.  Convenient and efficient synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones derived from 2-bromo-(2/3-substitutedphenyl)-1H-indene-1,3(2H)-diones.

Authors:  Satbir Mor; Suchita Sindhu
Journal:  RSC Adv       Date:  2019-04-25       Impact factor: 4.036

8.  Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities.

Authors:  Diego R Merchán-Arenas; Felipe Sojo; Francisco Arvelo; Vladimir V Kouznetsov
Journal:  RSC Adv       Date:  2020-11-19       Impact factor: 4.036

9.  Nickel(ii)-catalyzed tandem C(sp2)-H bond activation and annulation of arenes with gem-dibromoalkenes.

Authors:  Yun Shi; Meng-Sheng Li; Fangdong Zhang; Baohua Chen
Journal:  RSC Adv       Date:  2018-08-13       Impact factor: 3.361
  9 in total

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