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Literature DB >> 17588744

Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.

Shoukou Lee¹, Chihiro Shinji, Kiyoshi Ogura, Motomu Shimizu, Satoko Maeda, Mayumi Sato, Minoru Yoshida, Yuichi Hashimoto, Hiroyuki Miyachi.

Abstract

We designed and synthesized hydroxamic acid derivatives bearing a 4-(3-pyridyl)phenyl group as a cap structure, and found that they exhibit potent histone deacetylase (HDAC) inhibitory activity. A representative compound, 17a, showed more potent growth-inhibitory activity against pancreatic cancer cells and greater upregulation of p21(WAF1/CIP1) expression than the clinically used HDAC inhibitor suberoylanilide hydroxamic acid (Zolinza).

Entities: Chemical Disease Gene

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Year: 2007 PMID： 17588744 DOI： 10.1016/j.bmcl.2007.06.038

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

Review 1. Current evidence for histone deacetylase inhibitors in pancreatic cancer.

Authors: Ioannis Koutsounas; Constantinos Giaginis; Efstratios Patsouris; Stamatios Theocharis
Journal: World J Gastroenterol Date: 2013-02-14 Impact factor: 5.742

2. Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives.

Authors: Sandeep Kumar; Nikhil Kumar; Partha Roy; Sham M Sondhi
Journal: Mol Divers Date: 2013-08-27 Impact factor: 2.943

3. Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations.

Authors: Robert W Foster; Christopher J Tame; Helen C Hailes; Tom D Sheppard
Journal: Adv Synth Catal Date: 2013-08-12 Impact factor: 5.837

4. Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction.

Authors: Salvatore V Giofrè; Santa Cirmi; Raffaella Mancuso; Francesco Nicolò; Giuseppe Lanza; Laura Legnani; Agata Campisi; Maria A Chiacchio; Michele Navarra; Bartolo Gabriele; Roberto Romeo
Journal: Beilstein J Org Chem Date: 2016-12-20 Impact factor: 2.883

Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.

Review 1. Current evidence for histone deacetylase inhibitors in pancreatic cancer.

2. Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives.

3. Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations.

4. Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction.

5. Hydroxamic acid - A novel molecule for anticancer therapy.

6. Unprecedented selective homogeneous cobalt-catalysed reductive alkoxylation of cyclic imides under mild conditions.

7. Iridium(I)-Catalyzed Isoindolinone-Directed Branched-Selective Aromatic C-H Alkylation with Simple Alkenes.