Literature DB >> 23973655

Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort.

Jian Huang1, Xiao-Qing Lu1, Cui Zhang1, Jin Lu1, Guo-Yu Li2, Rui-Chao Lin3, Jin-Hui Wang4.   

Abstract

Four new ligustilides chuanxiongnolide R1 (1), chuanxiongnolide R2 (2), chuanxiongdiolide R1 (3) and chuanxiongdiolide R2 (4) together with eight known derivatives (5-12) were isolated from the root of Ligusticum chuanxiong Hort. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were confirmed via the circular dichroism (CD) spectrum. The anti-inflammatory assay in LPS-triggered RAW 264.7 macrophages was carried out on the twelve compounds. 1, 3, 5 and 6 showed significant inhibitory effects against LPS-induced NO production.
© 2013.

Entities:  

Keywords:  Anti-inflammatory activity; CD; Ligusticum chuanxiong Hort; Ligustilide

Mesh：

Substances：

Year:  2013        PMID： 23973655     DOI： 10.1016/j.fitote.2013.08.013

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  13 in total

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