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Literature DB >> 23934246

Spontaneous activation of [FeFe]-hydrogenases by an inorganic [2Fe] active site mimic.

Camilla Lambertz¹, Agnieszka Adamska-Venkates², Trevor Simmons³, Julian Esselborn¹, Gustav Berggren³, Jens Noth¹, Judith Siebel², Anja Hemschemeier¹, Vincent Artero³, Edward Reijerse², Marc Fontecave^3,4, Wolfgang Lubitz², Thomas Happe¹.

Abstract

Hydrogenases catalyze the formation of hydrogen. The cofactor ('H-cluster') of [FeFe]-hydrogenases consists of a [4Fe-4S] cluster bridged to a unique [2Fe] subcluster whose biosynthesis in vivo requires hydrogenase-specific maturases. Here we show that a chemical mimic of the [2Fe] subcluster can reconstitute apo-hydrogenase to full activity, independent of helper proteins. The assembled H-cluster is virtually indistinguishable from the native cofactor. This procedure will be a powerful tool for developing new artificial H₂-producing catalysts.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23934246 PMCID： PMC3795299 DOI： 10.1038/nchembio.1311

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

31 in total

Review 1. Structural and functional analogues of the active sites of the [Fe]-, [NiFe]-, and [FeFe]-hydrogenases.

Authors: Cédric Tard; Christopher J Pickett
Journal: Chem Rev Date: 2009-06 Impact factor: 60.622

2. The [FeFe]-hydrogenase maturase HydF from Clostridium acetobutylicum contains a CO and CN- ligated iron cofactor.

Authors: Ilka Czech; Alexey Silakov; Wolfgang Lubitz; Thomas Happe
Journal: FEBS Lett Date: 2009-12-14 Impact factor: 4.124

Review 3. [NiFe] and [FeFe] hydrogenases studied by advanced magnetic resonance techniques.

Authors: Wolfgang Lubitz; Eduard Reijerse; Maurice van Gastel
Journal: Chem Rev Date: 2007-09-11 Impact factor: 60.622

4. Identification and characterization of the "super-reduced" state of the H-cluster in [FeFe] hydrogenase: a new building block for the catalytic cycle?

Authors: Agnieszka Adamska; Alexey Silakov; Camilla Lambertz; Olaf Rüdiger; Thomas Happe; Edward Reijerse; Wolfgang Lubitz
Journal: Angew Chem Int Ed Engl Date: 2012-10-26 Impact factor: 15.336

5. Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG).

Authors: David W Mulder; Eric S Boyd; Ranjana Sarma; Rachel K Lange; James A Endrizzi; Joan B Broderick; John W Peters
Journal: Nature Date: 2010-04-25 Impact factor: 49.962

6. Pyruvate:ferredoxin oxidoreductase is coupled to light-independent hydrogen production in Chlamydomonas reinhardtii.

Authors: Jens Noth; Danuta Krawietz; Anja Hemschemeier; Thomas Happe
Journal: J Biol Chem Date: 2012-12-20 Impact factor: 5.157

7. Isolation and first EPR characterization of the [FeFe]-hydrogenases from green algae.

Authors: Christina Kamp; Alexey Silakov; Martin Winkler; Edward J Reijerse; Wolfgang Lubitz; Thomas Happe
Journal: Biochim Biophys Acta Date: 2008-02-21

8. Purification of His6-tagged Photosystem I from Chlamydomonas reinhardtii.

Authors: Galina Gulis; Kuppala V Narasimhulu; Lisa N Fox; Kevin E Redding
Journal: Photosynth Res Date: 2008-01-04 Impact factor: 3.573

9. The effects of pH and redox potential on the hydrogen production activity of the hydrogenase from Megasphaera elsdenii.

Authors: C van Dijk; C Veeger
Journal: Eur J Biochem Date: 1981-02

Review 10. Analytical approaches to photobiological hydrogen production in unicellular green algae.

Authors: Anja Hemschemeier; Anastasios Melis; Thomas Happe
Journal: Photosynth Res Date: 2009 Nov-Dec Impact factor: 3.573

79 in total

1. Atypical effect of temperature tuning on the insertion of the catalytic iron-sulfur center in a recombinant [FeFe]-hydrogenase.

Authors: Simone Morra; Alessandro Cordara; Gianfranco Gilardi; Francesca Valetti
Journal: Protein Sci Date: 2015-09-24 Impact factor: 6.725

2. Stepwise isotope editing of [FeFe]-hydrogenases exposes cofactor dynamics.

Authors: Moritz Senger; Stefan Mebs; Jifu Duan; Florian Wittkamp; Ulf-Peter Apfel; Joachim Heberle; Michael Haumann; Sven Timo Stripp
Journal: Proc Natl Acad Sci U S A Date: 2016-07-18 Impact factor: 11.205

Review 3. Biosynthesis of nitrogenase metalloclusters.

Authors: Markus W Ribbe; Yilin Hu; Keith O Hodgson; Britt Hedman
Journal: Chem Rev Date: 2013-12-13 Impact factor: 60.622

4. Metalloenzymes: Cutting out the middleman.

Authors: Souvik Roy; Anne K Jones
Journal: Nat Chem Biol Date: 2013-08-18 Impact factor: 15.040

Review 5. Hydrogenase Enzymes and Their Synthetic Models: The Role of Metal Hydrides.

Authors: David Schilter; James M Camara; Mioy T Huynh; Sharon Hammes-Schiffer; Thomas B Rauchfuss
Journal: Chem Rev Date: 2016-06-29 Impact factor: 60.622

6. N-Substituted Derivatives of the Azadithiolate Cofactor from the [FeFe] Hydrogenases: Stability and Complexation.

Authors: Raja Angamuthu; Chi-Shian Chen; Tyler R Cochrane; Danielle L Gray; David Schilter; Olbelina A Ulloa; Thomas B Rauchfuss
Journal: Inorg Chem Date: 2015-05-22 Impact factor: 5.165

7. The final steps of [FeFe]-hydrogenase maturation.

Authors: Oliver Lampret; Julian Esselborn; Rieke Haas; Andreas Rutz; Rosalind L Booth; Leonie Kertess; Florian Wittkamp; Clare F Megarity; Fraser A Armstrong; Martin Winkler; Thomas Happe
Journal: Proc Natl Acad Sci U S A Date: 2019-07-23 Impact factor: 11.205