Literature DB >> 23873826

Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.

Yu Cheng1, Ramin Morshed, Shih-Hsun Cheng, Alex Tobias, Brenda Auffinger, Derek A Wainwright, Lingjiao Zhang, Catherine Yunis, Yu Han, Chin-Tu Chen, Leu-Wei Lo, Karen S Aboody, Atique U Ahmed, Maciej S Lesniak.   

Abstract

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  doxorubicin; drug delivery; glioblastoma; glioma; mesoporous silica nanoparticles; neural stem cells; targeted delivery

Mesh：

Substances：

Year:  2013        PMID： 23873826      PMCID： PMC3879136          DOI： 10.1002/smll.201301111

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  29 in total

1.  Nanoparticles in medicine: therapeutic applications and developments.

Authors:  L Zhang; F X Gu; J M Chan; A Z Wang; R S Langer; O C Farokhzad
Journal:  Clin Pharmacol Ther       Date:  2007-10-24       Impact factor: 6.875

2.  Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells.

Authors:  Hiroshi Yukawa; Yukimasa Kagami; Masaki Watanabe; Koichi Oishi; Yoshitaka Miyamoto; Yukihiro Okamoto; Manabu Tokeshi; Noritada Kaji; Hirofumi Noguchi; Kenji Ono; Makoto Sawada; Yoshinobu Baba; Nobuyuki Hamajima; Shuji Hayashi
Journal:  Biomaterials       Date:  2010-02-19       Impact factor: 12.479

Review 3.  The use of neural stem cells in cancer gene therapy: predicting the path to the clinic.

Authors:  Atique U Ahmed; Nikita G Alexiades; Maciej S Lesniak
Journal:  Curr Opin Mol Ther       Date:  2010-10

4.  Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.

Authors:  K S Aboody; A Brown; N G Rainov; K A Bower; S Liu; W Yang; J E Small; U Herrlinger; V Ourednik; P M Black; X O Breakefield; E Y Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

5.  Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.

Authors:  Maciej S Lesniak; Urvashi Upadhyay; Rory Goodwin; Betty Tyler; Henry Brem
Journal:  Anticancer Res       Date:  2005 Nov-Dec       Impact factor: 2.480

6.  Acid pH in tumors and its potential for therapeutic exploitation.

Authors:  I F Tannock; D Rotin
Journal:  Cancer Res       Date:  1989-08-15       Impact factor: 12.701

7.  Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo.

Authors:  M A Tyler; I V Ulasov; A M Sonabend; S Nandi; Y Han; S Marler; J Roth; M S Lesniak
Journal:  Gene Ther       Date:  2008-12-11       Impact factor: 5.250

Review 8.  Nanoparticle therapeutics: an emerging treatment modality for cancer.

Authors:  Mark E Davis; Zhuo Georgia Chen; Dong M Shin
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

Review 9.  Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles.

Authors:  Zibin Gao; Linan Zhang; Jie Hu; Yongjun Sun
Journal:  Nanomedicine       Date:  2012-07-05       Impact factor: 5.307

10.  The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers.

Authors:  Carlee E Ashley; Eric C Carnes; Genevieve K Phillips; David Padilla; Paul N Durfee; Page A Brown; Tracey N Hanna; Juewen Liu; Brandy Phillips; Mark B Carter; Nick J Carroll; Xingmao Jiang; Darren R Dunphy; Cheryl L Willman; Dimiter N Petsev; Deborah G Evans; Atul N Parikh; Bryce Chackerian; Walker Wharton; David S Peabody; C Jeffrey Brinker
Journal:  Nat Mater       Date:  2011-04-17       Impact factor: 43.841
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  33 in total

1.  Prognostication of Survival Outcomes in Patients Diagnosed with Glioblastoma.

Authors:  Damir Nizamutdinov; Eileen M Stock; Jad A Dandashi; Eliana A Vasquez; Ying Mao; Samantha Dayawansa; Jun Zhang; Erxi Wu; Ekokobe Fonkem; Jason H Huang
Journal:  World Neurosurg       Date:  2017-09-23       Impact factor: 2.104

Review 2.  Engineered Mesenchymal Stem Cells for Targeting Solid Tumors: Therapeutic Potential beyond Regenerative Therapy.

Authors:  Shen Cheng; Susheel Kumar Nethi; Sneha Rathi; Buddhadev Layek; Swayam Prabha
Journal:  J Pharmacol Exp Ther       Date:  2019-06-07       Impact factor: 4.030

3.  Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy.

Authors:  Rachael Mooney; Yiming Weng; Elizabeth Garcia; Sukhada Bhojane; Leslie Smith-Powell; Seung U Kim; Alexander J Annala; Karen S Aboody; Jacob M Berlin
Journal:  J Control Release       Date:  2014-06-18       Impact factor: 9.776

Review 4.  Exploiting homing abilities of cell carriers: Targeted delivery of nanoparticles for cancer therapy.

Authors:  Pamela Tiet; Jacob M Berlin
Journal:  Biochem Pharmacol       Date:  2017-09-21       Impact factor: 5.858

Review 5.  Sui generis: gene therapy and delivery systems for the treatment of glioblastoma.

Authors:  J Robert Kane; Jason Miska; Jacob S Young; Deepak Kanojia; Julius W Kim; Maciej S Lesniak
Journal:  Neuro Oncol       Date:  2015-03       Impact factor: 12.300

6.  Nano-Engineered Mesenchymal Stem Cells Increase Therapeutic Efficacy of Anticancer Drug Through True Active Tumor Targeting.

Authors:  Buddhadev Layek; Tanmoy Sadhukha; Jayanth Panyam; Swayam Prabha
Journal:  Mol Cancer Ther       Date:  2018-03-28       Impact factor: 6.261

Review 7.  Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Authors:  Surya K Mallapragada; Timothy M Brenza; JoEllyn M McMillan; Balaji Narasimhan; Donald S Sakaguchi; Anup D Sharma; Svitlana Zbarska; Howard E Gendelman
Journal:  Nanomedicine       Date:  2015-01-31       Impact factor: 5.307

8.  Cytotoxic Engineered Induced Neural Stem Cells as an Intravenous Therapy for Primary Non-Small Cell Lung Cancer and Triple-Negative Breast Cancer.

Authors:  Alison R Mercer-Smith; Wulin Jiang; Juli R Bago; Alain Valdivia; Morrent Thang; Alex S Woodell; Stephanie A Montgomery; Kevin T Sheets; Carey K Anders; Shawn D Hingtgen
Journal:  Mol Cancer Ther       Date:  2021-08-25       Impact factor: 6.261

Review 9.  Multifunctional nanoparticles for brain tumor imaging and therapy.

Authors:  Yu Cheng; Ramin A Morshed; Brenda Auffinger; Alex L Tobias; Maciej S Lesniak
Journal:  Adv Drug Deliv Rev       Date:  2013-09-20       Impact factor: 15.470

10.  Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma.

Authors:  Shih-Hsun Cheng; Dou Yu; Hsiu-Ming Tsai; Ramin A Morshed; Deepak Kanojia; Leu-Wei Lo; Lara Leoni; Yureve Govind; Lingjiao Zhang; Karen S Aboody; Maciej S Lesniak; Chin-Tu Chen; Irina V Balyasnikova
Journal:  J Nucl Med       Date:  2015-11-12       Impact factor: 10.057
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