Literature DB >> 22772046

Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles.

Zibin Gao1, Linan Zhang, Jie Hu, Yongjun Sun.   

Abstract

The targeted delivery of anticancer agents is a promising field in anticancer therapy. Mesenchymal stem cells (MSCs) have inherent tumor-tropic and migratory properties, which allow them to serve as vehicles for targeted drug delivery systems for isolated tumors and metastatic diseases. MSCs have been successfully studied and discussed as a vehicle for cancer gene therapy. However, MSCs have not yet been discussed adequately as a potential vehicle for traditional anticancer drugs. In this review, we will examine the potential of MSCs as a targeted-delivery vehicle for anticancer drug-loaded nanoparticles (NPs), summarize various challenges, and discuss possible solutions for these challenges. FROM THE CLINICAL EDITOR: In this review, the feasibility of mesenchymal stem cell-based targeted delivery of anticancer agents is discussed.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22772046     DOI： 10.1016/j.nano.2012.06.003

Source DB:  PubMed          Journal:  Nanomedicine        ISSN： 1549-9634            Impact factor:   5.307


  43 in total

1.  Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer.

Authors:  Perry T Yin; Shreyas Shah; Nicholas J Pasquale; Olga B Garbuzenko; Tamara Minko; Ki-Bum Lee
Journal:  Biomaterials       Date:  2015-11-12       Impact factor: 12.479

2.  Intravital imaging of mesenchymal stem cell trafficking and association with platelets and neutrophils.

Authors:  Grace Sock Leng Teo; Zijiang Yang; Christopher V Carman; Jeffrey M Karp; Charles P Lin
Journal:  Stem Cells       Date:  2015-01       Impact factor: 6.277

3.  Nano-Engineered Mesenchymal Stem Cells Increase Therapeutic Efficacy of Anticancer Drug Through True Active Tumor Targeting.

Authors:  Buddhadev Layek; Tanmoy Sadhukha; Jayanth Panyam; Swayam Prabha
Journal:  Mol Cancer Ther       Date:  2018-03-28       Impact factor: 6.261

4.  A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer.

Authors:  Oren Levy; W Nathaniel Brennen; Edward Han; David Marc Rosen; Juliet Musabeyezu; Helia Safaee; Sudhir Ranganath; Jessica Ngai; Martina Heinelt; Yuka Milton; Hao Wang; Sachin H Bhagchandani; Nitin Joshi; Neil Bhowmick; Samuel R Denmeade; John T Isaacs; Jeffrey M Karp
Journal:  Biomaterials       Date:  2016-03-17       Impact factor: 12.479

Review 5.  Molecular targets in aortic aneurysm for establishing novel management paradigms.

Authors:  Chengkai Hu; Kai Zhu; Jun Li; Chunsheng Wang; Lao Lai
Journal:  J Thorac Dis       Date:  2017-11       Impact factor: 2.895

6.  Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation.

Authors:  Ronnie L Shammas; Andrew M Fales; Bridget M Crawford; Amy J Wisdom; Gayathri R Devi; David A Brown; Tuan Vo-Dinh; Scott T Hollenbeck
Journal:  Plast Reconstr Surg       Date:  2017-04       Impact factor: 4.730

Review 7.  Bone regeneration in the stem cell era: safe play for the patient?

Authors:  Estella Musacchio; Nicola Veronese
Journal:  Clin Rheumatol       Date:  2017-02-25       Impact factor: 2.980

8.  Translational Approaches towards Cancer Gene Therapy: Hurdles and Hopes.

Authors:  Jaleh Barar; Yadollah Omidi
Journal:  Bioimpacts       Date:  2012-09-22

Review 9.  Cell Membrane Coating Nanotechnology.

Authors:  Ronnie H Fang; Ashley V Kroll; Weiwei Gao; Liangfang Zhang
Journal:  Adv Mater       Date:  2018-03-27       Impact factor: 30.849

10.  Tumor necrosis factor-α/CD40 ligand-engineered mesenchymal stem cells greatly enhanced the antitumor immune response and lifespan in mice.

Authors:  Somayeh Shahrokhi; Saeed Daneshmandi; Farid Menaa
Journal:  Hum Gene Ther       Date:  2014-03-04       Impact factor: 5.695
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