AIM: Mean corpuscular volume (MCV) is a measure of size of red blood cells. Recently a few studies showed an association of macrocytosis with all-cause mortality. We aimed to assess the relationship of MCV with cardiovascular (CV) morbidity and mortality in patients with chronic kidney disease (CKD), and the effect of MCV on endothelial function. METHODS: This is an observational cohort study with a prospectively maintained cohort of patients with stage 1-5 CKD. Estimated glomerular filtration rate (eGFR), flow mediated dilatation (FMD) and laboratory values were measured at baseline. Multivariate linear and Cox regression analyses were used to predict independent associations of FMD and composite CV events, respectively. RESULTS: A total of 309 patients were included in the study. In contrast to anaemia MCV did not show a significant change among CKD groups. MCV was an independent predictor of FMD in addition to serum haemoglobin, CRP, diabetes, systolic blood pressure (SBP) and eGFR. Median MCV value was 85 fl. Kaplan-Meier analysis showed that at 38 months the survival rate was 97.6% in the group with MCV < 85 compared to 81.6% in the arm with MCV ≥ 85 (P < 0.001, log-rank test). Cox regression analysis showed MCV as a predictor of composite CV events independent of major confounding factors. CONCLUSION: This is the first study in the literature showing an independent association of MCV and FMD. Our results also determined MCV as an independent predictor of composite CV events independent of anaemia, inflammation, diabetes and eGFR in patients with CKD.
AIM: Mean corpuscular volume (MCV) is a measure of size of red blood cells. Recently a few studies showed an association of macrocytosis with all-cause mortality. We aimed to assess the relationship of MCV with cardiovascular (CV) morbidity and mortality in patients with chronic kidney disease (CKD), and the effect of MCV on endothelial function. METHODS: This is an observational cohort study with a prospectively maintained cohort of patients with stage 1-5 CKD. Estimated glomerular filtration rate (eGFR), flow mediated dilatation (FMD) and laboratory values were measured at baseline. Multivariate linear and Cox regression analyses were used to predict independent associations of FMD and composite CV events, respectively. RESULTS: A total of 309 patients were included in the study. In contrast to anaemia MCV did not show a significant change among CKD groups. MCV was an independent predictor of FMD in addition to serum haemoglobin, CRP, diabetes, systolic blood pressure (SBP) and eGFR. Median MCV value was 85 fl. Kaplan-Meier analysis showed that at 38 months the survival rate was 97.6% in the group with MCV < 85 compared to 81.6% in the arm with MCV ≥ 85 (P < 0.001, log-rank test). Cox regression analysis showed MCV as a predictor of composite CV events independent of major confounding factors. CONCLUSION: This is the first study in the literature showing an independent association of MCV and FMD. Our results also determined MCV as an independent predictor of composite CV events independent of anaemia, inflammation, diabetes and eGFR in patients with CKD.
Authors: Mehmet Kanbay; Baris Afsar; Dimitrie Siriopol; Hilmi Umut Unal; Murat Karaman; Mutlu Saglam; Tayfun Eyileten; Mustafa Gezer; Samet Verim; Yusuf Oguz; Abdulgaffar Vural; Alberto Ortiz; Richard J Johnson; Adrian Covic; Mahmut Ilker Yilmaz Journal: Int Urol Nephrol Date: 2016-03-23 Impact factor: 2.370
Authors: Katarzyna Brzeźniakiewicz-Janus; Marcus Daniel Lancé; Andrzej Tukiendorf; Tomasz Janus; Mirosław Franków; Joanna Rupa-Matysek; Zuzanna Walkowiak; Lidia Gil Journal: Dis Markers Date: 2020-07-16 Impact factor: 3.434
Authors: Katarzyna Brzeźniakiewicz-Janus; Joanna Rupa-Matysek; Andrzej Tukiendorf; Tomasz Janus; Mirosław Franków; Marcus Daniel Lancé; Lidia Gil Journal: Stem Cell Rev Rep Date: 2020-08 Impact factor: 5.739
Authors: Chani Jo Hodonsky; Claudia Schurmann; Ursula M Schick; Jonathan Kocarnik; Ran Tao; Frank Ja van Rooij; Christina Wassel; Steve Buyske; Myriam Fornage; Lucia A Hindorff; James S Floyd; Santhi K Ganesh; Dan-Yu Lin; Kari E North; Alex P Reiner; Ruth Jf Loos; Charles Kooperberg; Christy L Avery Journal: Am J Hematol Date: 2018-06-15 Impact factor: 13.265