Sherry R Chemler1, Michael T Bovino. 1. Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York, USA.
Abstract
Catalytic aminohalogenation methods enable the regio- and stereoselective vicinal difunctionalization of alkynes, allenes and alkenes with amine and halogen moieties. A range of protocols and reaction mechanisms including organometallic, Lewis base, Lewis acid and Brønsted acid catalysis have been disclosed, enabling the regio- and stereoselective synthesis of halogen-functionalized acyclic amines and nitrogen heterocycles. Recent advances including aminofluorination and catalytic enantioselective aminohalogenation reactions are summarized in this review.
Catalytic aminohalogenation methods enable the regio- and stereoselective vicinal difunctionalization of n class="Chemical">alkynes, allenes and alkenes with amine and halogen moieties. A range of protocols and reaction mechanisms including organometallic, Lewis base, Lewis acid and Brønsted acid catalysis have been disclosed, enabling the regio- and stereoselective synthesis of halogen-functionalized acyclic amines and nitrogen heterocycles. Recent advances including aminofluorination and catalytic enantioselective aminohalogenation reactions are summarized in this review.
Authors: A Nakagawa; Y Iwai; H Hashimoto; N Miyazaki; R Oiwa; Y Takahashi; A Hirano; N Shibukawa; Y Kojima; S Omura Journal: J Antibiot (Tokyo) Date: 1981-11 Impact factor: 2.649
Authors: Daniel Weiliang Tay; Ivan Tan Tsoi; Jun Cheng Er; Gulice Yiu Chung Leung; Ying-Yeung Yeung Journal: Org Lett Date: 2013-03-05 Impact factor: 6.005