Performance validation of deformable image registration in the pelvic region.

Patients undergoing radiotherapy will inevitably show anatomical changes during the course of treatment. These can be weight loss, tumour shrinkage, and organ motion or filling changes. For advanced and adaptive radiotherapy (ART) information about anatomical changes must be extracted from repeated images in order to be able to evaluate and manage these changes. Deformable image registration (DIR) is a tool that can be used to efficiently gather information about anatomical changes. The aim of the present study was to evaluate the performance of two DIR methods for automatic organ at risk (OAR) contour propagation. Datasets from ten gynaecological patients having repeated computed tomography (CT) and cone beam computed tomography (CBCT) scans were collected. Contours were delineated on the planning CT and on every repeated scan by an expert clinician. DIR using our in-house developed featurelet-based method and the iPlan(®) BrainLab treatment planning system software was performed with the planning CT as reference and a selection of repeated scans as the target dataset. The planning CT contours were deformed using the resulting deformation fields and compared to the manually defined contours. Dice's similarity coefficients (DSCs) were calculated for each fractional patient scan structure, comparing the volume overlap using DIR with that using rigid registration only. No significant improvement in volume overlap was found after DIR as compared with rigid registration, independent of which image modality or DIR method was used. DIR needs to be further improved in order to facilitate contour propagation in the pelvic region in ART approaches.