Literature DB >> 23774735

Pitfalls of predicting complex traits from SNPs.

Naomi R Wray1, Jian Yang, Ben J Hayes, Alkes L Price, Michael E Goddard, Peter M Visscher.   

Abstract

The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of results.

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Year:  2013        PMID： 23774735      PMCID： PMC4096801          DOI： 10.1038/nrg3457

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  77 in total

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8.  A commentary on Pitfalls of predicting complex traits from SNPs.

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