Literature DB >> 23774266

Building unique bonds to fight misplaced DNA.

Caio T Fagundes1, Luke A J O'Neill.   

Abstract

A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the structure of the enzyme involved in the synthesis of this second messenger and identifies this cyclic dinucleotide as a unique compound in metazoan cell signaling.

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Year:  2013        PMID： 23774266      PMCID： PMC3760622          DOI： 10.1038/cr.2013.81

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  9 in total

1.  Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon.

Authors:  Kazuishi Kubota; Kaori Nakahara; Toshiaki Ohtsuka; Shuku Yoshida; Junko Kawaguchi; Yoko Fujita; Yohei Ozeki; Ayako Hara; Chigusa Yoshimura; Hidehiko Furukawa; Hideyuki Haruyama; Kimihisa Ichikawa; Makoto Yamashita; Tatsuji Matsuoka; Yasuteru Iijima
Journal:  J Biol Chem       Date:  2004-06-30       Impact factor: 5.157

Review 2.  Sensing the messenger: the diverse ways that bacteria signal through c-di-GMP.

Authors:  Petya Violinova Krasteva; Krista Michelle Giglio; Holger Sondermann
Journal:  Protein Sci       Date:  2012-06-05       Impact factor: 6.725

3.  Immunology. Sensing the dark side of DNA.

Authors:  Luke A J O'Neill
Journal:  Science       Date:  2013-02-15       Impact factor: 47.728

4.  Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Authors:  Jiaxi Wu; Lijun Sun; Xiang Chen; Fenghe Du; Heping Shi; Chuo Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

5.  Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Authors:  Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

6.  Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.

Authors:  Jesse Donovan; Matthew Dufner; Alexei Korennykh
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-14       Impact factor: 11.205

Review 7.  Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.

Authors:  Ute Römling; Michael Y Galperin; Mark Gomelsky
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

Review 8.  Immune sensing of DNA.

Authors:  Søren R Paludan; Andrew G Bowie
Journal:  Immunity       Date:  2013-05-23       Impact factor: 31.745

9.  Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Authors:  Pu Gao; Manuel Ascano; Yang Wu; Winfried Barchet; Barbara L Gaffney; Thomas Zillinger; Artem A Serganov; Yizhou Liu; Roger A Jones; Gunther Hartmann; Thomas Tuschl; Dinshaw J Patel
Journal:  Cell       Date:  2013-05-03       Impact factor: 41.582
  9 in total

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