Literature DB >> 23712821

Enzyme-directed assembly of a nanoparticle probe in tumor tissue.

Miao-Ping Chien1, Matthew P Thompson, Christopher V Barback, Ti-Hsuan Ku, David J Hall, Nathan C Gianneschi.   

Abstract

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  enzyme-responsive; in vivo probe; micelle; nanoparticles; peptide

Mesh：

Substances：

Year:  2013        PMID： 23712821      PMCID： PMC4108424          DOI： 10.1002/adma.201300823

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


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  18 in total

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5.  Polycatechol Nanoparticle MRI Contrast Agents.

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8.  Dye Encapsulation in Polynorbornene Micelles.

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Review 10.  What is new in nanoparticle-based photoacoustic imaging?

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