Literature DB >> 26305446

Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.

Mary M Nguyen1, Andrea S Carlini2, Miao-Ping Chien2, Sonya Sonnenberg1, Colin Luo3, Rebecca L Braden1, Kent G Osborn4, Yiwen Li2, Nathan C Gianneschi2, Karen L Christman1.   

Abstract

A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  MMPs; enzyme-responsive; intravenous injection; myocardial infarction; nanoparticles

Mesh：

Substances：

Year:  2015        PMID： 26305446      PMCID： PMC4699559          DOI： 10.1002/adma.201502003

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  42 in total

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