Literature DB >> 23698584

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription.

William A Pastor1, L Aravind, Anjana Rao.   

Abstract

In many organisms, the methylation of cytosine in DNA has a key role in silencing 'parasitic' DNA elements, regulating transcription and establishing cellular identity. The recent discovery that ten-eleven translocation (TET) proteins are 5-methylcytosine oxidases has provided several chemically plausible pathways for the reversal of DNA methylation, thus triggering a paradigm shift in our understanding of how changes in DNA methylation are coupled to cell differentiation, embryonic development and cancer.

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Year:  2013        PMID： 23698584      PMCID： PMC3804139          DOI： 10.1038/nrm3589

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  186 in total

1.  Active repression of methylated genes by the chromosomal protein MBD1.

Authors:  H H Ng; P Jeppesen; A Bird
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

2.  Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.

Authors:  B Hendrich; J Guy; B Ramsahoye; V A Wilson; A Bird
Journal:  Genes Dev       Date:  2001-03-15       Impact factor: 11.361

3.  Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Authors:  Daniel Cortázar; Christophe Kunz; Jim Selfridge; Teresa Lettieri; Yusuke Saito; Eilidh MacDougall; Annika Wirz; David Schuermann; Angelika L Jacobs; Fredy Siegrist; Roland Steinacher; Josef Jiricny; Adrian Bird; Primo Schär
Journal:  Nature       Date:  2011-01-30       Impact factor: 49.962

4.  Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.

Authors:  Shireen A Sarraf; Irina Stancheva
Journal:  Mol Cell       Date:  2004-08-27       Impact factor: 17.970

5.  Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

Authors:  Henri G A M van Luenen; Carol Farris; Sabrina Jan; Paul-Andre Genest; Pankaj Tripathi; Arno Velds; Ron M Kerkhoven; Marja Nieuwland; Andrew Haydock; Gowthaman Ramasamy; Saara Vainio; Tatjana Heidebrecht; Anastassis Perrakis; Ludo Pagie; Bas van Steensel; Peter J Myler; Piet Borst
Journal:  Cell       Date:  2012-08-31       Impact factor: 41.582

Review 6.  Unraveling the molecular pathophysiology of myelodysplastic syndromes.

Authors:  Rafael Bejar; Ross Levine; Benjamin L Ebert
Journal:  J Clin Oncol       Date:  2011-01-10       Impact factor: 44.544

7.  Modulation of DNA binding protein affinity directly affects target site demethylation.

Authors:  I G Lin; T J Tomzynski; Q Ou; C L Hsieh
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

8.  The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.

Authors:  Sofia Gkountela; Ziwei Li; John J Vincent; Kelvin X Zhang; Angela Chen; Matteo Pellegrini; Amander T Clark
Journal:  Nat Cell Biol       Date:  2012-12-16       Impact factor: 28.824

9.  Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.

Authors:  Claudia A Doege; Keiichi Inoue; Toru Yamashita; David B Rhee; Skylar Travis; Ryousuke Fujita; Paolo Guarnieri; Govind Bhagat; William B Vanti; Alan Shih; Ross L Levine; Sara Nik; Emily I Chen; Asa Abeliovich
Journal:  Nature       Date:  2012-08-30       Impact factor: 49.962

Review 10.  TET family proteins and their role in stem cell differentiation and transformation.

Authors:  Luisa Cimmino; Omar Abdel-Wahab; Ross L Levine; Iannis Aifantis
Journal:  Cell Stem Cell       Date:  2011-09-02       Impact factor: 24.633
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  367 in total

Review 1.  Single-cell epigenomics: techniques and emerging applications.

Authors:  Omer Schwartzman; Amos Tanay
Journal:  Nat Rev Genet       Date:  2015-10-13       Impact factor: 53.242

Review 2.  Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease.

Authors:  Michel DuPage; Jeffrey A Bluestone
Journal:  Nat Rev Immunol       Date:  2016-02-15       Impact factor: 53.106

Review 3.  Mutation-Driven Therapy in MDS.

Authors:  David M Swoboda; David A Sallman
Journal:  Curr Hematol Malig Rep       Date:  2019-12       Impact factor: 3.952

4.  Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation.

Authors:  Liang Xu; Ying-Chu Chen; Jenny Chong; Andrea Fin; Lisa S McCoy; Jun Xu; Chao Zhang; Dong Wang
Journal:  Angew Chem Int Ed Engl       Date:  2014-08-27       Impact factor: 15.336

5.  TET family dioxygenases and the TET activator vitamin C in immune responses and cancer.

Authors:  Xiaojing Yue; Anjana Rao
Journal:  Blood       Date:  2020-09-17       Impact factor: 22.113

Review 6.  How to stomach an epigenetic insult: the gastric cancer epigenome.

Authors:  Nisha Padmanabhan; Toshikazu Ushijima; Patrick Tan
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2017-05-17       Impact factor: 46.802

Review 7.  Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology.

Authors:  Krithika Vaidyanathan; Sean Durning; Lance Wells
Journal:  Crit Rev Biochem Mol Biol       Date:  2014-02-14       Impact factor: 8.250

8.  Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

Authors:  Angela C Cheung; Nicholas F LaRusso; Gregory J Gores; Konstantinos N Lazaridis
Journal:  Semin Liver Dis       Date:  2017-05-31       Impact factor: 6.115

9.  The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

Authors:  Jean-Pierre Etchegaray; Lukas Chavez; Yun Huang; Kenneth N Ross; Jiho Choi; Barbara Martinez-Pastor; Ryan M Walsh; Cesar A Sommer; Matthias Lienhard; Adrianne Gladden; Sita Kugel; Dafne M Silberman; Sridhar Ramaswamy; Gustavo Mostoslavsky; Konrad Hochedlinger; Alon Goren; Anjana Rao; Raul Mostoslavsky
Journal:  Nat Cell Biol       Date:  2015-04-27       Impact factor: 28.824

10.  Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.

Authors:  Minmin Liu; Hitoshi Ohtani; Wanding Zhou; Andreas Due Ørskov; Jessica Charlet; Yang W Zhang; Hui Shen; Stephen B Baylin; Gangning Liang; Kirsten Grønbæk; Peter A Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-29       Impact factor: 11.205
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