Literature DB >> 23664375

The AID-induced DNA damage response in chromatin.

Jeremy A Daniel1, André Nussenzweig.   

Abstract

Chemical modifications to the DNA and histone protein components of chromatin can modulate gene expression and genome stability. Understanding the physiological impact of changes in chromatin structure remains an important question in biology. As one example, in order to generate antibody diversity with somatic hypermutation and class switch recombination, chromatin must be made accessible for activation-induced cytidine deaminase (AID)-mediated deamination of cytosines in DNA. These lesions are recognized and removed by various DNA repair pathways but, if not handled properly, can lead to formation of oncogenic chromosomal translocations. In this review, we focus the discussion on how chromatin-modifying activities and -binding proteins contribute to the native chromatin environment in which AID-induced DNA damage is targeted and repaired. Outstanding questions remain regarding the direct roles of histone posttranslational modifications and the significance of AID function outside of antibody diversity.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23664375      PMCID： PMC3658174          DOI： 10.1016/j.molcel.2013.04.017

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  126 in total

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Authors:  Ivan M Muñoz; John Rouse
Journal:  EMBO Rep       Date:  2009-02-20       Impact factor: 8.807

2.  Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.

Authors:  Albert G Tsai; Haihui Lu; Sathees C Raghavan; Markus Muschen; Chih-Lin Hsieh; Michael R Lieber
Journal:  Cell       Date:  2008-12-12       Impact factor: 41.582

3.  Two levels of protection for the B cell genome during somatic hypermutation.

Authors:  Man Liu; Jamie L Duke; Daniel J Richter; Carola G Vinuesa; Christopher C Goodnow; Steven H Kleinstein; David G Schatz
Journal:  Nature       Date:  2008-02-14       Impact factor: 49.962

4.  RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.

Authors:  Adam G W Matthews; Alex J Kuo; Santiago Ramón-Maiques; Sunmi Han; Karen S Champagne; Dmitri Ivanov; Mercedes Gallardo; Dylan Carney; Peggie Cheung; David N Ciccone; Kay L Walter; Paul J Utz; Yang Shi; Tatiana G Kutateladze; Wei Yang; Or Gozani; Marjorie A Oettinger
Journal:  Nature       Date:  2007-11-21       Impact factor: 49.962

5.  Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

Authors:  Zihua Gong; Young-Wook Cho; Ja-Eun Kim; Kai Ge; Junjie Chen
Journal:  J Biol Chem       Date:  2009-01-05       Impact factor: 5.157

Review 6.  Mechanism and regulation of class switch recombination.

Authors:  Janet Stavnezer; Jeroen E J Guikema; Carol E Schrader
Journal:  Annu Rev Immunol       Date:  2008       Impact factor: 28.527

Review 7.  GammaH2AX and cancer.

Authors:  William M Bonner; Christophe E Redon; Jennifer S Dickey; Asako J Nakamura; Olga A Sedelnikova; Stéphanie Solier; Yves Pommier
Journal:  Nat Rev Cancer       Date:  2008-11-13       Impact factor: 60.716

8.  Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus.

Authors:  Muslima Chowdhury; Omid Forouhi; Sandeep Dayal; Natalie McCloskey; Hannah J Gould; Gary Felsenfeld; David J Fear
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-03       Impact factor: 11.205

9.  53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

Authors:  Simone Difilippantonio; Eric Gapud; Nancy Wong; Ching-Yu Huang; Grace Mahowald; Hua Tang Chen; Michael J Kruhlak; Elsa Callen; Ferenc Livak; Michel C Nussenzweig; Barry P Sleckman; André Nussenzweig
Journal:  Nature       Date:  2008-10-19       Impact factor: 49.962

10.  Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.

Authors:  Ivan M Munoz; Paul A Jowsey; Rachel Toth; John Rouse
Journal:  Nucleic Acids Res       Date:  2007-08-08       Impact factor: 16.971
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  41 in total

1.  Molecular biology: Unequal opportunity during class switching.

Authors:  Javier M Di Noia
Journal:  Nature       Date:  2015-08-26       Impact factor: 49.962

2.  The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair.

Authors:  Fengshan Liang; Adam S Miller; Caroline Tang; David Maranon; Elizabeth A Williamson; Robert Hromas; Claudia Wiese; Weixing Zhao; Patrick Sung; Gary M Kupfer
Journal:  J Biol Chem       Date:  2020-04-29       Impact factor: 5.157

Review 3.  Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms.

Authors:  Monali NandyMazumdar; Irina Artsimovitch
Journal:  Bioessays       Date:  2015-01-15       Impact factor: 4.345

4.  The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.

Authors:  Shaliny Ramachandran; Dania Haddad; Conglei Li; Michael X Le; Alexanda K Ling; Clare C So; Rajeev M Nepal; Jennifer L Gommerman; Kefei Yu; Troy Ketela; Jason Moffat; Alberto Martin
Journal:  Cell Rep       Date:  2016-05-05       Impact factor: 9.423

Review 5.  RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.

Authors:  Brice Laffleur; Uttiya Basu; Junghyun Lim
Journal:  J Mol Biol       Date:  2017-01-07       Impact factor: 5.469

6.  Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.

Authors:  Brice Laffleur; Junghyun Lim; Wanwei Zhang; Yiyun Chen; Evangelos Pefanis; Jonathan Bizarro; Carolina R Batista; Lijing Wu; Aris N Economides; Jiguang Wang; Uttiya Basu
Journal:  Nat Genet       Date:  2021-02-01       Impact factor: 38.330

Review 7.  Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.

Authors:  Joyce K Hwang; Frederick W Alt; Leng-Siew Yeap
Journal:  Microbiol Spectr       Date:  2015-02

8.  Checkpoint kinase 2 is required for efficient immunoglobulin diversification.

Authors:  Kathrin Davari; Samantha Frankenberger; Angelika Schmidt; Nils-Sebastian Tomi; Berit Jungnickel
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

9.  A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

Authors:  Kayleigh Herrick-Reynolds; Bharat Vaidyanathan; Joseph N Pucella; Bao Q Vuong; Anna J Ucher; Nina M Donghia; Xiwen Gu; Laura Nicolas; Urszula Nowak; Numa Rahman; Matthew P Strout; Kevin D Mills; Janet Stavnezer; Jayanta Chaudhuri
Journal:  Nat Immunol       Date:  2013-10-06       Impact factor: 25.606

Review 10.  Generation and repair of AID-initiated DNA lesions in B lymphocytes.

Authors:  Zhangguo Chen; Jing H Wang
Journal:  Front Med       Date:  2014-04-21       Impact factor: 4.592
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