Literature DB >> 19005492

GammaH2AX and cancer.

William M Bonner1, Christophe E Redon, Jennifer S Dickey, Asako J Nakamura, Olga A Sedelnikova, Stéphanie Solier, Yves Pommier.   

Abstract

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.

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Year:  2008        PMID： 19005492      PMCID： PMC3094856          DOI： 10.1038/nrc2523

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  167 in total

1.  H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.

Authors:  Oscar Fernandez-Capetillo; Shantha K Mahadevaiah; Arkady Celeste; Peter J Romanienko; R Daniel Camerini-Otero; William M Bonner; Katia Manova; Paul Burgoyne; André Nussenzweig
Journal:  Dev Cell       Date:  2003-04       Impact factor: 12.270

2.  A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.

Authors:  Michael-Christopher Keogh; Jung-Ae Kim; Michael Downey; Jeffrey Fillingham; Dipanjan Chowdhury; Jacob C Harrison; Megumi Onishi; Nira Datta; Sarah Galicia; Andrew Emili; Judy Lieberman; Xuetong Shen; Stephen Buratowski; James E Haber; Daniel Durocher; Jack F Greenblatt; Nevan J Krogan
Journal:  Nature       Date:  2005-11-20       Impact factor: 49.962

3.  MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

Authors:  Zhenkun Lou; Katherine Minter-Dykhouse; Sonia Franco; Monica Gostissa; Melissa A Rivera; Arkady Celeste; John P Manis; Jan van Deursen; André Nussenzweig; Tanya T Paull; Frederick W Alt; Junjie Chen
Journal:  Mol Cell       Date:  2006-01-20       Impact factor: 17.970

4.  Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.

Authors:  Tsutomu Shimura; Michael J Torres; Melvenia M Martin; V Ashutosh Rao; Yves Pommier; Mari Katsura; Kiyoshi Miyagawa; Mirit I Aladjem
Journal:  J Mol Biol       Date:  2007-11-13       Impact factor: 5.469

5.  Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

Authors:  Chengrong Lu; Feng Zhu; Yong-Yeon Cho; Faqing Tang; Tatyana Zykova; Wei-ya Ma; Ann M Bode; Zigang Dong
Journal:  Mol Cell       Date:  2006-07-07       Impact factor: 17.970

6.  Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Authors:  Arkady Celeste; Oscar Fernandez-Capetillo; Michael J Kruhlak; Duane R Pilch; David W Staudt; Alicia Lee; Robert F Bonner; William M Bonner; André Nussenzweig
Journal:  Nat Cell Biol       Date:  2003-07       Impact factor: 28.824

7.  Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.

Authors:  Christophe Redon; Duane R Pilch; Emmy P Rogakou; Ann H Orr; Noel F Lowndes; William M Bonner
Journal:  EMBO Rep       Date:  2003-07       Impact factor: 8.807

8.  Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans.

Authors:  Karlis Briviba; Berenike A Stracke; Corinna E Rüfer; Bernhard Watzl; Franco P Weibel; Achim Bub
Journal:  J Agric Food Chem       Date:  2007-08-16       Impact factor: 5.279

9.  Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Authors:  Yan Zhao; Huw D Thomas; Michael A Batey; Ian G Cowell; Caroline J Richardson; Roger J Griffin; A Hilary Calvert; David R Newell; Graeme C M Smith; Nicola J Curtin
Journal:  Cancer Res       Date:  2006-05-15       Impact factor: 12.701

10.  An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans.

Authors:  Ismail Hassan Ismail; Tabasum Imran Wadhra; Ola Hammarsten
Journal:  Nucleic Acids Res       Date:  2007-02-06       Impact factor: 16.971
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  716 in total

1.  Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression.

Authors:  Michael S Bobola; Douglas D Kolstoe; A Blank; John R Silber
Journal:  Mol Cancer Ther       Date:  2010-05       Impact factor: 6.261

2.  Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.

Authors:  Robert J Kinders; Melinda Hollingshead; Scott Lawrence; Jiuping Ji; Brian Tabb; William M Bonner; Yves Pommier; Larry Rubinstein; Yvonne A Evrard; Ralph E Parchment; Joseph Tomaszewski; James H Doroshow
Journal:  Clin Cancer Res       Date:  2010-10-05       Impact factor: 12.531

3.  Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type-specific induction of apoptosis and mitotic catastrophe.

Authors:  R Cotugno; R Fortunato; A Santoro; D Gallotta; A Braca; N De Tommasi; M A Belisario
Journal:  Cell Prolif       Date:  2011-12-14       Impact factor: 6.831

4.  Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells.

Authors:  Xiaofang Huo; Stefanie Juergens; Xi Zhang; Davood Rezaei; Chunhua Yu; Eric D Strauch; Jian-Ying Wang; Edaire Cheng; Frank Meyer; David H Wang; Qiuyang Zhang; Stuart J Spechler; Rhonda F Souza
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-06-02       Impact factor: 4.052

5.  Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

Authors:  Dhriti Sooryakumar; Thomas S Dexheimer; Beverly A Teicher; Yves Pommier
Journal:  Mol Cancer Ther       Date:  2011-06-02       Impact factor: 6.261

6.  Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.

Authors:  Nikita Avvakumov; Marie-Eve Lalonde; Nehmé Saksouk; Eric Paquet; Karen C Glass; Anne-Julie Landry; Yannick Doyon; Christelle Cayrou; Geneviève A Robitaille; Darren E Richard; Xiang-Jiao Yang; Tatiana G Kutateladze; Jacques Côté
Journal:  Mol Cell Biol       Date:  2011-12-05       Impact factor: 4.272

7.  A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Authors:  Peter M Bruno; Yunpeng Liu; Ga Young Park; Junko Murai; Catherine E Koch; Timothy J Eisen; Justin R Pritchard; Yves Pommier; Stephen J Lippard; Michael T Hemann
Journal:  Nat Med       Date:  2017-02-27       Impact factor: 53.440

8.  Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

Authors:  Wei Lei; Xu-Hui Feng; Wen-Bo Deng; Hua Ni; Zhi-Rong Zhang; Bo Jia; Xin-Ling Yang; Tong-Song Wang; Ji-Long Liu; Ren-Wei Su; Xiao-Huan Liang; Qian-Rong Qi; Zeng-Ming Yang
Journal:  J Biol Chem       Date:  2012-03-08       Impact factor: 5.157

9.  Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication.

Authors:  Jonathan K Mitchell; Paul D Friesen
Journal:  J Virol       Date:  2012-10-03       Impact factor: 5.103

Review 10.  DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.

Authors:  Henning Willers; Liliana Gheorghiu; Qi Liu; Jason A Efstathiou; Lori J Wirth; Mechthild Krause; Cläre von Neubeck
Journal:  Semin Radiat Oncol       Date:  2015-05-14       Impact factor: 5.934
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