PURPOSE: Two-dimensional J-resolved localized and semi-localized by adiabatic selective refocusing (LASER and semi-LASER) spectroscopy, named "J-resolved LASER" and "J-resolved semi-LASER", were introduced to suppress chemical shift artifacts, additional J-refocused artifactual peaks from spatially dependent J-coupling evolution, and sensitivity to radiofrequency (RF) field inhomogeneity. METHODS: Three pairs of adiabatic pulses were employed for voxel localization in J-resolved LASER and two pairs in J-resolved semi-LASER. The first half of t1 period was inserted between the last pair of adiabatic pulses, which was proposed in this work to obtain two-dimensional adiabatic J-resolved spectra of human brain for the first time. Phantom and human experiments were performed to demonstrate their feasibility and advantages over conventional J-resolved spectroscopy (JPRESS). RESULTS: Compared to JPRESS, J-resolved LASER or J-resolved semi-LASER exhibited significant suppression of chemical shift artifacts and additional J-refocused peaks from spatially dependent J-coupling evolution, and demonstrated insensitivity to the change of RF frequency offset over large bandwidth. CONCLUSION: Experiments on phantoms and human brains verified the feasibility and strengths of two-dimensional adiabatic J-resolved spectroscopy at 3T. This technique is expected to advance the application of in vivo two-dimensional MR spectroscopy at 3T and higher field strengths for more reliable and accurate quantification of metabolites.
PURPOSE: Two-dimensional J-resolved localized and semi-localized by adiabatic selective refocusing (LASER and semi-LASER) spectroscopy, named "J-resolved LASER" and "J-resolved semi-LASER", were introduced to suppress chemical shift artifacts, additional J-refocused artifactual peaks from spatially dependent J-coupling evolution, and sensitivity to radiofrequency (RF) field inhomogeneity. METHODS: Three pairs of adiabatic pulses were employed for voxel localization in J-resolved LASER and two pairs in J-resolved semi-LASER. The first half of t1 period was inserted between the last pair of adiabatic pulses, which was proposed in this work to obtain two-dimensional adiabatic J-resolved spectra of human brain for the first time. Phantom and human experiments were performed to demonstrate their feasibility and advantages over conventional J-resolved spectroscopy (JPRESS). RESULTS: Compared to JPRESS, J-resolved LASER or J-resolved semi-LASER exhibited significant suppression of chemical shift artifacts and additional J-refocused peaks from spatially dependent J-coupling evolution, and demonstrated insensitivity to the change of RF frequency offset over large bandwidth. CONCLUSION: Experiments on phantoms and human brains verified the feasibility and strengths of two-dimensional adiabatic J-resolved spectroscopy at 3T. This technique is expected to advance the application of in vivo two-dimensional MR spectroscopy at 3T and higher field strengths for more reliable and accurate quantification of metabolites.
Authors: Anna Andreychenko; Vincent O Boer; Catalina S Arteaga de Castro; Peter R Luijten; Dennis W J Klomp Journal: Magn Reson Med Date: 2011-12-28 Impact factor: 4.668
Authors: Ofer M Gonen; Bradford A Moffat; Patrick Kwan; Terence J O'Brien; Patricia M Desmond; Elaine Lui Journal: Front Neurosci Date: 2020-09-15 Impact factor: 4.677
Authors: Lihong Tang; Yibo Zhao; Yudu Li; Rong Guo; Bryan Clifford; Georges El Fakhri; Chao Ma; Zhi-Pei Liang; Jie Luo Journal: Magn Reson Med Date: 2020-07-29 Impact factor: 4.668